Deng Shaoxiong, Qiu Yibin, Zhuang Zhanwei, Wu Jie, Li Xuehua, Ruan Donglin, Xu Cineng, Zheng Enqing, Yang Ming, Cai Gengyuan, Yang Jie, Wu Zhenfang, Huang Sixiu
College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou 510642, China.
Animals (Basel). 2023 Jul 26;13(15):2414. doi: 10.3390/ani13152414.
Body conformation is the most direct production index, which can fully reflect pig growth status and is closely related to critical economic traits. In this study, we conducted a genome-wide association study (GWAS) on body conformation traits in a population of 1518 Duroc × (Landrace × Yorkshire) commercial pigs. These traits included body length (BL), body height (BH), chest circumference (CC), abdominal circumference (AC), and waist circumference (WC). Both the mixed linear model (MLM) and fixed and random model circulating probability unification (FarmCPU) approaches were employed for the analysis. Our findings revealed 60 significant single nucleotide polymorphisms (SNPs) associated with these body conformation traits in the crossbred pig population. Specifically, sixteen SNPs were significantly associated with BL, three SNPs with BH, thirteen SNPs with CC, twelve SNPs with AC, and sixteen SNPs with WC. Moreover, we identified several promising candidate genes located within the genomic regions associated with body conformation traits. These candidate genes include , , , , , , , , , , and . Furthermore, our analysis revealed a novel significant quantitative trait locus (QTL) on SSC7 specifically associated with waist circumference, spanning an 84 kb interval. Overall, the identification of these significant SNPs and potential candidate genes in crossbred commercial pigs enhances our understanding of the genetic basis underlying body conformation traits. Additionally, these findings provide valuable genetic resources for pig breeding programs.
体型是最直接的生产指标，它能充分反映猪的生长状况，且与关键经济性状密切相关。在本研究中，我们对1518头杜洛克×（长白猪×大白猪）商品猪群体的体型性状进行了全基因组关联研究（GWAS）。这些性状包括体长（BL）、体高（BH）、胸围（CC）、腹围（AC）和腰围（WC）。分析采用了混合线性模型（MLM）和固定与随机模型循环概率统一法（FarmCPU）。我们的研究结果揭示了在该杂交猪群体中与这些体型性状相关的60个显著单核苷酸多态性（SNP）。具体而言，16个SNP与体长显著相关，3个SNP与体高显著相关，13个SNP与胸围显著相关，12个SNP与腹围显著相关，16个SNP与腰围显著相关。此外，我们在与体型性状相关的基因组区域内鉴定出了几个有前景的候选基因。这些候选基因包括 ， ， ， ， ， ， ， ， ， ， 和 。此外，我们的分析在7号染色体上发现了一个与腰围特异性相关的新的显著数量性状位点（QTL），跨度为84 kb区间。总体而言，在杂交商品猪中鉴定出这些显著的SNP和潜在候选基因，增强了我们对体型性状遗传基础的理解。此外，这些发现为猪育种计划提供了宝贵的遗传资源。
