Barreno-Rocha Sonia Guadalupe, Guzmán-Silahua Sandra, Cardona-Muñoz Ernesto Germán, Zavala-Cerna Maria Guadalupe, Muñoz Gaytan David Eduardo, Riebeling-Navarro Carlos, Rubio-Jurado Benjamín, Nava-Zavala Arnulfo Hernán
Unidad de Investigación Epidemiológica y en Servicios de Salud, CMNO OOAD, Jalisco, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.
Programa de Doctorado en Farmacología, Departamento de Fisiología, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Healthcare (Basel). 2023 Aug 6;11(15):2210. doi: 10.3390/healthcare11152210.
(1) Background: Non-Hodgkin Lymphoma is a neoplasm that can significantly compromise the immune system, but timely assessment can change the patient outcome. In cancer, the activation of the immune system could lead to the secretion of autoantibodies. (2) Methods: A retrospective cohort study was performed from 2017 to 2019 in patients with Non-Hodgkin Lymphoma diagnosed with a biopsy. (3) Results: We included 39 patients who were newly diagnosed, untreated, and without any autoimmune disease previously reported. Thirty patients had the presence of autoantibodies (antiphospholipid antibodies, anti-cytoplasmic neutrophils antibodies, antinuclear antibodies), and nine were without autoantibodies. There were no statistical differences among groups regarding clinical, demographic, staging, and prognosis characteristics. Also, there were no differences in the outcomes of the patients after finishing chemotherapy and one year after initiating treatment. (4) Conclusions: Further investigations must be conducted regarding an extended panel of autoantibodies because the panel of autoantibodies in this study did not show a relationship between the presence and the clinical outcome of the patients.
(1) 背景：非霍奇金淋巴瘤是一种可严重损害免疫系统的肿瘤，但及时评估可改变患者预后。在癌症中，免疫系统的激活可能导致自身抗体的分泌。(2) 方法：2017年至2019年对经活检确诊为非霍奇金淋巴瘤的患者进行了一项回顾性队列研究。(3) 结果：我们纳入了39例新诊断、未治疗且既往无任何自身免疫性疾病报告的患者。30例患者存在自身抗体（抗磷脂抗体、抗中性粒细胞胞浆抗体、抗核抗体），9例无自身抗体。各组在临床、人口统计学、分期和预后特征方面无统计学差异。此外，化疗结束后及开始治疗一年后患者的结局也无差异。(4) 结论：必须对更多种类的自身抗体进行进一步研究，因为本研究中的自身抗体种类未显示出患者自身抗体的存在与临床结局之间的关系。
