Tyurin Vladimir S, Shkirdova Alena O, Koifman Oscar I, Zamilatskov Ilya A
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Department of Chemistry and Technology of Macromolecular Compounds, Ivanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia.
Molecules. 2023 Jul 31;28(15):5782. doi: 10.3390/molecules28155782.
This review presents a strategy for obtaining various functional derivatives of tetrapyrrole compounds based on transformations of unsaturated carbon-oxygen and carbon-carbon bonds of the substituents at the position (-formyl, vinyl, and ethynyl porphyrins). First, synthetic approaches to the preparation of these precursors are described. Then diverse pathways for the transformations of the multipotent synthons are discussed, revealing a variety of products of such reactions. The structures, electronic, and optical properties of the compounds obtained by the methods under consideration are analyzed. In addition, there is an overview of the applications of the products obtained. Biomedical use of the compounds is among the most important. Finally, the advantages of using the reviewed synthetic strategy to obtain dyes with targeted properties are highlighted.
本综述提出了一种基于对卟啉化合物（-甲酰基、乙烯基和乙炔基卟啉）取代基的不饱和碳-氧键和碳-碳键进行转化来获得各种功能衍生物的策略。首先，描述了制备这些前体的合成方法。然后讨论了多能合成子转化的各种途径，揭示了此类反应的多种产物。分析了通过所考虑方法获得的化合物的结构、电子和光学性质。此外，还概述了所得产物的应用。化合物的生物医学用途是最重要的应用之一。最后，强调了使用所综述的合成策略来获得具有靶向性质染料的优势。
