Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Molecules. 2023 Aug 3;28(15):5841. doi: 10.3390/molecules28155841.
Organotin (IV) dithiocarbamate has recently received attention as a therapeutic agent among organotin (IV) compounds. The individual properties of the organotin (IV) and dithiocarbamate moieties in the hybrid complex form a synergy of action that stimulates increased biological activity. Organotin (IV) components have been shown to play a crucial role in cytotoxicity. The biological effects of organotin compounds are believed to be influenced by the number of Sn-C bonds and the number and nature of alkyl or aryl substituents within the organotin structure. Ligands target and react with molecules while preventing unwanted changes in the biomolecules. Organotin (IV) dithiocarbamate compounds have also been shown to have a broad range of cellular, biochemical, and molecular effects, with their toxicity largely determined by their structure. Continuing the investigation of the cytotoxicity of organotin (IV) dithiocarbamates, this mini-review delves into the appropriate method for synthesis and discusses the elemental and spectroscopic analyses and potential cytotoxic effects of these compounds from articles published since 2010.
有机锡（IV）二硫代氨基甲酸盐最近作为有机锡（IV）化合物中的一种治疗剂受到关注。 杂化配合物中有机锡（IV）和二硫代氨基甲酸盐部分的单独性质形成协同作用，刺激生物活性增加。 已经表明有机锡（IV）成分在细胞毒性中起关键作用。 据信，有机锡化合物的生物学效应受 Sn-C 键的数量以及有机锡结构内的烷基或芳基取代基的数量和性质的影响。 配体针对并与分子反应，同时防止生物分子发生不需要的变化。 有机锡（IV）二硫代氨基甲酸盐化合物还显示出具有广泛的细胞，生化和分子作用，其毒性在很大程度上取决于其结构。 本综述深入探讨了有机锡（IV）二硫代氨基甲酸盐的细胞毒性的研究，探讨了适当的合成方法，并讨论了自 2010 年以来发表的文章中这些化合物的元素和光谱分析以及潜在的细胞毒性作用。
