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癌症治疗的新方法和程序:当前观点。

New approaches and procedures for cancer treatment: Current perspectives.

作者信息

Debela Dejene Tolossa, Muzazu Seke Gy, Heraro Kidist Digamo, Ndalama Maureen Tayamika, Mesele Betelhiem Woldemedhin, Haile Dagimawi Chilot, Kitui Sophia Khalayi, Manyazewal Tsegahun

机构信息

Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Enteric Diseases and Vaccines Research Unit, Centre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.

出版信息

SAGE Open Med. 2021 Aug 12;9:20503121211034366. doi: 10.1177/20503121211034366. eCollection 2021.

Abstract

Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been a highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Current methods in oncology focus on the development of safe and efficient cancer nanomedicines. Stem cell therapy has brought promising efficacy in regenerating and repairing diseased or damaged tissues by targeting both primary and metastatic cancer foci, and nanoparticles brought new diagnostic and therapeutic options. Targeted therapy possessed breakthrough potential inhibiting the growth and spread of specific cancer cells, causing less damage to healthy cells. Ablation therapy has emerged as a minimally invasive procedure that burns or freezes cancers without the need for open surgery. Natural antioxidants demonstrated potential tracking down free radicals and neutralizing their harmful effects thereby treating or preventing cancer. Several new technologies are currently under research in clinical trials, and some of them have already been approved. This review presented an update on recent advances and breakthroughs in cancer therapies.

摘要

癌症是一个全球性的健康问题,全球六分之一的死亡都与之相关。治疗癌症一直是一个高度复杂的过程。传统的治疗方法,如手术、化疗和放疗,一直在使用,而近年来也取得了重大进展,包括干细胞疗法、靶向治疗、消融治疗、纳米颗粒、天然抗氧化剂、放射疗法、化学动力疗法、声动力疗法和铁死亡疗法。肿瘤学的当前方法侧重于开发安全有效的癌症纳米药物。干细胞疗法通过靶向原发性和转移性癌灶,在再生和修复患病或受损组织方面带来了有前景的疗效,纳米颗粒带来了新的诊断和治疗选择。靶向治疗具有抑制特定癌细胞生长和扩散的突破性潜力,对健康细胞的损害较小。消融疗法已成为一种微创手术,无需进行开放手术即可烧灼或冷冻癌症。天然抗氧化剂显示出追踪自由基并中和其有害影响从而治疗或预防癌症的潜力。目前有几种新技术正在临床试验中研究,其中一些已经获得批准。本综述介绍了癌症治疗的最新进展和突破。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb74/8366192/6e87dee0af79/10.1177_20503121211034366-fig1.jpg

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