Lela Ludovica, Russo Daniela, De Biasio Filomena, Gorgoglione Domenico, Ostuni Angela, Ponticelli Maria, Milella Luigi
Department of Science, University of Basilicata, V.le Ateneo Lucano 10, 85100 Potenza, Italy.
Spinoff Bioactiplant s.r.l., Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Plants (Basel). 2023 Aug 3;12(15):2859. doi: 10.3390/plants12152859.
Obesity is widely associated with intestine barrier impairment, nonalcoholic fatty liver disease (NAFLD) outbreaks, oxidative stress, and inflammation. In a previous investigation, the L. growing in Basilicata Region has demonstrated to have antioxidant activity; hence this investigation was aimed to evaluate for the first time the antilipidemic and anti-inflammatory activity of the Lucanian L. peel extract in vitro on OA-treated HepG2 and Caco-2 cell lines. It was shown that the extract could reduce lipogenesis by down-regulating SREBP-1c and HMGCR expression and fatty acid -oxidation by up-regulating PPAR, CPT1A, and UCP2 expression. In addition, the L. peel extract might also improve oxidative stress by reducing endoplasmic reticulum stress and regulating the Nrf2 and Nf-κB molecular pathways. Altogether, these results demonstrated for the first time the possible application of the Lucanian peel extract for preventing obesity and managing NAFLD.
肥胖与肠道屏障受损、非酒精性脂肪性肝病（NAFLD）爆发、氧化应激和炎症密切相关。在先前的一项研究中，生长在巴西利卡塔地区的[具体名称未给出，推测为某种植物]已被证明具有抗氧化活性；因此，本研究旨在首次评估卢卡尼亚[具体名称未给出，推测为某种植物]果皮提取物在体外对油酸（OA）处理的HepG2和Caco - 2细胞系的抗血脂和抗炎活性。结果表明，该提取物可通过下调SREBP - 1c和HMGCR表达来减少脂肪生成，并通过上调PPAR、CPT1A和UCP2表达来促进脂肪酸氧化。此外，[具体名称未给出，推测为某种植物]果皮提取物还可能通过减轻内质网应激和调节Nrf2和Nf - κB分子途径来改善氧化应激。总之，这些结果首次证明了卢卡尼亚[具体名称未给出，推测为某种植物]果皮提取物在预防肥胖和管理NAFLD方面的潜在应用价值。
