Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Molecules. 2021 Feb 11;26(4):954. doi: 10.3390/molecules26040954.
For centuries, natural medicines have represented the only option for treating human diseases and, nowadays, plant phytochemicals are considered as promising compounds to treat or prevent chronic conditions. Among them, hop flowers ( L.), typically used in brewing industries to give the typical aroma and flavor to beer, have attracted particular attention for their health promoting properties. Several studies and human interventional trials have demonstrated the beneficial effects of these molecules on weight gain, lipid metabolism, glucose homeostasis, insulin sensitivities, and inflammation by acting on different targets. All these activities suggest a possible role of bitter hop acid in preventing metabolic syndrome and its related diseases. A systematic quest on PubMed and Scopus databases was performed to identify pre-clinical and clinical studies focusing on this topic. This systematic review summarizes the results obtained by different cell lines, animal models, and human interventional trials to propose -α-acids as medical nutrition therapy to treat or prevent metabolic syndrome and its related disorders as diabetes, dislipidemia inflammation, etc.
几个世纪以来，天然药物一直是治疗人类疾病的唯一选择，而如今，植物中的植物化学物质被认为是治疗或预防慢性疾病的有前途的化合物。其中，啤酒花（Humulus lupulus L.）花常用于酿造行业，为啤酒赋予独特的香气和风味，因其具有促进健康的特性而备受关注。多项研究和人体干预试验已经证明，这些分子通过作用于不同靶点，对体重增加、脂代谢、葡萄糖稳态、胰岛素敏感性和炎症具有有益的影响。所有这些活动都表明苦酸啤酒花酸在预防代谢综合征及其相关疾病方面可能具有作用。在 PubMed 和 Scopus 数据库中进行了系统搜索，以确定专注于该主题的临床前和临床研究。本系统综述总结了不同细胞系、动物模型和人体干预试验的结果，提出 -α-酸作为医学营养疗法，用于治疗或预防代谢综合征及其相关疾病，如糖尿病、血脂异常、炎症等。
