Department of Gastroenterology, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia.
Department of Gastroenterology, Hepatology and Clinical Nutrition, Clinical Hospital Dubrava, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
Nutrients. 2023 Jul 27;15(15):3335. doi: 10.3390/nu15153335.
Bioelectrical impedance analysis (BIA) is a body composition assessment method. We aimed to determine its accuracy in the detection of sarcopenia in patients with liver cirrhosis (LC), using skeletal muscle index (SMI) at the level of third lumbar vertebra (L3-SMI) obtained using multislice computed tomography as the reference method. Patients with LC were enrolled in the period October 2019-March 2022 and follow-ups were conducted until January 2023. Their BIA parameters were compared against L3-SMI, and BIA cut-off values were proposed using AUROC analysis. Patients underwent outcome analysis based on obtained clinical characteristics. A total of 106 patients were included. We found a fair correlation between BIA parameters with the L3-SMI. We determined cut-off values of ≤11.1 kg/m for BIA-SMI (Se 73%, Sp 66%, AUROC 0.737, < 0.001) and ≤5.05° for phase angle (PA) (Se 79%, Sp 60%, AUROC 0.762, < 0.001) in the detection of sarcopenia. The relative risk of death was 2.2 times higher in patients with skeletal muscle mass (SMM) ≤ 36.5 kg. SMM was significantly associated with outcome in Kaplan-Meier analysis. This non-invasive and simple method that showed fair performances and a very good outcome prediction could provide for the unmet need for fast and affordable detection of sarcopenia in patients with LC and should be further evaluated.
生物电阻抗分析（BIA）是一种身体成分评估方法。我们旨在使用多层计算机断层扫描（MSCT）获得的第三腰椎水平骨骼肌指数（SMI）作为参考方法，确定 BIA 在检测肝硬化（LC）患者肌少症中的准确性。2019 年 10 月至 2022 年 3 月期间招募了 LC 患者，并进行随访至 2023 年 1 月。将他们的 BIA 参数与 L3-SMI 进行比较，并使用 AUROC 分析提出 BIA 截断值。根据获得的临床特征对患者进行结局分析。共纳入 106 例患者。我们发现 BIA 参数与 L3-SMI 之间存在适度相关性。我们确定了 BIA-SMI≤11.1kg/m（Se 为 73%，Sp 为 66%，AUROC 为 0.737，<0.001）和相位角（PA）≤5.05°（Se 为 79%，Sp 为 60%，AUROC 为 0.762，<0.001）的截断值，可用于检测肌少症。骨骼肌质量（SMM）≤36.5kg 的患者死亡的相对风险增加 2.2 倍。SMM 在 Kaplan-Meier 分析中与结局显著相关。这种非侵入性且简单的方法表现出良好的性能和出色的预后预测能力，可以满足快速且负担得起的检测 LC 患者肌少症的需求，应进一步评估。
