Department of Nutrition and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland.
Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, 90-419 Lodz, Poland.
Nutrients. 2023 Aug 7;15(15):3479. doi: 10.3390/nu15153479.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is often accompanied by malnutrition that manifests itself as nutrient deficiencies and body mass loss or deficit. The purpose of this study is to evaluate the utility of albumin, transferrin and transthyretin levels in the assessment of nutritional status and IBD activity. The case-control study included 82 IBD patients. The serum concentrations of albumin, transferrin and transthyretine were determined by a quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Significantly lower median concentrations of albumin were found in the IBD patients vs. controls and in CD patients compared to the UC patients. Significantly higher median transthyretin concentrations were found in the IBD patients compared to the healthy subjects. There were no significant differences in median transferrin concentrations between the IBD patients and the healthy subjects. Significantly higher albumin levels were found in IBD patients in remission compared to patients with moderate and severe exacerbation of IBD symptoms. There were no significant differences in the median transferrin or transthyretin levels in patients with IBD depending on disease activity. No differences were identified in the median transferrin or transthyretin levels in the IBD patients according to nutritional status. The median albumin concentrations in the IBD subjects were significantly higher in patients with normal body fat, normal BMI and normal waist circumferences compared to those with an abnormal nutritional status. The albumin levels reflect both nutritional status and disease activity and therefore cannot be considered a prognostic marker of malnutrition in IBD. As regards the utility of transferrin and transthyretin as markers of activity and nutritional status in IBD patients, further studies are required.
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），常伴有营养不良，表现为营养缺乏和体重减轻或不足。本研究旨在评估白蛋白、转铁蛋白和甲状腺素结合蛋白水平在评估营养状况和 IBD 活动中的作用。该病例对照研究纳入了 82 例 IBD 患者。通过定量夹心酶联免疫吸附试验（ELISA）测定血清白蛋白、转铁蛋白和甲状腺素结合蛋白浓度。与对照组和 UC 患者相比，IBD 患者的白蛋白中位数浓度显著降低。与健康受试者相比，IBD 患者的甲状腺素结合蛋白中位数浓度显著升高。IBD 患者和健康受试者的转铁蛋白中位数浓度无显著差异。与中度和重度 IBD 症状加重的患者相比，缓解期 IBD 患者的白蛋白水平显著升高。根据疾病活动度，IBD 患者的转铁蛋白或甲状腺素结合蛋白中位数浓度无显著差异。根据营养状况，IBD 患者的转铁蛋白或甲状腺素结合蛋白中位数浓度无差异。与营养状况异常的患者相比，IBD 患者中体脂正常、BMI 正常和腰围正常的患者的白蛋白中位数浓度显著升高。白蛋白水平反映了营养状况和疾病活动度，因此不能作为 IBD 营养不良的预后标志物。关于转铁蛋白和甲状腺素结合蛋白作为 IBD 患者活动和营养状况的标志物的效用，需要进一步研究。
