Wang Chenxi, Yu Chenxi, Chang Hongkai, Song Jiaqi, Zhang Shuai, Zhao Jianguo, Wang Jiyan, Wang Tao, Qi Qi, Shan Changliang
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Expert Opin Ther Targets. 2023 Jul-Dec;27(8):733-743. doi: 10.1080/14728222.2023.2247558. Epub 2023 Aug 18.
Ovarian cancer (OC) is a gynecological tumor disease, which is usually diagnosed at an advanced stage and has a poor prognosis. It has been established that the glucose metabolism rate of cancer cells is significantly higher than that of normal cells, and the pentose phosphate pathway (PPP) is an important branch pathway for glucose metabolism. Glucose-6-phosphate dehydrogenase (G6PD) is the key rate-limiting enzyme in the PPP, which plays an important role in the initiation and development of cancer (such as OC), and has been considered as a promisinganti-cancer target.
In this review, based on the structure and biological function of G6PD, recent research on the roles of G6PD in the progression, metastasis, and chemoresistance of OC are summarized and accompanied by proposed molecular mechanisms, which may provide a systematic understanding of targeting G6PD for the treatment of patients with OC.
Accumulating evidence demonstrates that G6PD is a promising target of cancer. The development of G6PD inhibitors for cancer treatment merits broad application prospects.
卵巢癌（OC）是一种妇科肿瘤疾病，通常在晚期被诊断出来，预后较差。已经证实癌细胞的葡萄糖代谢率明显高于正常细胞，而磷酸戊糖途径（PPP）是葡萄糖代谢的一条重要分支途径。葡萄糖-6-磷酸脱氢酶（G6PD）是PPP中的关键限速酶，在癌症（如OC）的发生和发展中起重要作用，并被认为是一个有前景的抗癌靶点。
在本综述中，基于G6PD的结构和生物学功能，总结了G6PD在OC进展、转移和化疗耐药中的作用的最新研究，并提出了相关分子机制，这可能为靶向G6PD治疗OC患者提供系统的认识。
越来越多的证据表明G6PD是一个有前景的癌症靶点。开发用于癌症治疗的G6PD抑制剂具有广阔的应用前景。
