Abdullah Anusha, Kumbrink Jörg, Liokatis Paris, Mock Andreas, Abdullah Ahdiya, Dewenter Ina, Obermeier Katharina Theresa
Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig Maximilian University of Munich (LMU), 80337 Munich, Germany.
Institute of Pathology, Faculty of Medicine, Ludwig Maximilian University of Munich (LMU), 80337 Munich, Germany.
Cancers (Basel). 2024 Dec 27;17(1):48. doi: 10.3390/cancers17010048.
Skin cancer is one of the most prevalent malignancies in the world, with increasing incidence. In 2022, the World Health Organization estimated over 1.5 million new diagnoses of skin malignancies, primarily affecting the older population. Surgical excision, particularly in the head and neck area, can cause aesthetic deficits and significantly impair patients' quality of life. There are limited therapeutic options for advanced skin malignancies, and the development of resistance to targeted therapy further restricts treatment choices. Cancer metabolism may offer a novel approach to overcome these challenges. The pentose phosphate pathway, along with its rate-limiting enzyme, glucose-6-phosphate dehydrogenase, is essential for both the antioxidative response and the synthesis of ribonucleotides and may play a critical role in the proliferation and growth of cancer cells. This review examines current knowledge on the correlation between altered glucose-6-phosphate dehydrogenase expression and activity and skin cancer progression, with the aim of identifying a potential therapeutic target for treating advanced skin cancer.
皮肤癌是世界上最常见的恶性肿瘤之一，发病率呈上升趋势。2022年，世界卫生组织估计有超过150万例皮肤恶性肿瘤新诊断病例，主要影响老年人群。手术切除，尤其是在头颈部区域，会导致美学缺陷并严重损害患者的生活质量。对于晚期皮肤恶性肿瘤，治疗选择有限，而对靶向治疗产生耐药性进一步限制了治疗选择。癌症代谢可能提供一种克服这些挑战的新方法。磷酸戊糖途径及其限速酶葡萄糖-6-磷酸脱氢酶，对于抗氧化反应以及核糖核苷酸的合成至关重要，并且可能在癌细胞的增殖和生长中发挥关键作用。本综述探讨了关于葡萄糖-6-磷酸脱氢酶表达和活性改变与皮肤癌进展之间相关性的现有知识，旨在确定治疗晚期皮肤癌的潜在治疗靶点。
