Fine J M, Allain J P, Rochu D, Marneux M
Clin Chem. 1986 Oct;32(10):1991-3.
Circulating proalbumin in humans has been described in two distinct events: genetic variants of proalbumin related to mutations at the cleavage site, and normal proalbumin related to an abnormal cleaving enzyme system. We report a case of acquired proalbuminemia that appeared after an acute episode of hepatitis related to the delta agent, in a chronic carrier of hepatitis B virus. This component, not present in normal plasma, was identified as proalbumin by immunological methods. It was indistinguishable from the molecule normally present in hepatocytes as judged by electrophoretic mobility, limited susceptibility to tryptic digestion, and its inability to bind labeled Ni. We suggest that this release of proalbumin is related to the concurrent presence of both hepatitis B and delta virus in some of the infected hepatocytes.
与裂解位点突变相关的前清蛋白基因变异，以及与异常裂解酶系统相关的正常前清蛋白。我们报告了一例获得性前清蛋白血症病例，该病例出现在一名慢性乙型肝炎病毒携带者发生与丁型肝炎病毒相关的急性肝炎发作之后。这种在正常血浆中不存在的成分通过免疫学方法被鉴定为前清蛋白。通过电泳迁移率、对胰蛋白酶消化的有限敏感性以及其无法结合标记镍来判断，它与正常存在于肝细胞中的分子无法区分。我们认为这种前清蛋白的释放与一些受感染肝细胞中同时存在乙型肝炎病毒和丁型肝炎病毒有关。
