Curran R A, O'Neill H J, Connolly J H
Department of Bacteriology, Royal Victoria Hospital, Belfast.
Ulster Med J. 1991 Oct;60(2):159-63.
The incidence of hepatitis delta virus (HDV) infection in Northern Ireland (1970-1989) was tested by enzyme linked immunosorbent assay in 401 hepatitis B surface antigen (HBsAg) positive sera. Hepatitis delta antigen (HDAg) was tested in 388 patients and antibody to delta antigen (anti-HD) in 401 patients. Four patients (1.03%) were HDAg positive. Nine patients (2.24%) were positive for anti-HD and after acid pre-treatment of sera from eight of these patients, five were positive for HDAg. The overall incidence of HDV markers was 3.27%, which reflects the low incidence in HBsAg carriers in Northern Ireland (who were in high risk groups for delta hepatitis). The use of acid treatment of the sera to break up antigen/antibody complexes has been a useful technological improvement in the identification of this virus.
采用酶联免疫吸附试验对北爱尔兰（1970 - 1989年）401份乙型肝炎表面抗原（HBsAg）阳性血清检测丁型肝炎病毒（HDV）感染率。对388例患者检测丁型肝炎抗原（HDAg），对401例患者检测抗丁型抗原抗体（抗-HD）。4例患者（1.03%）HDAg阳性。9例患者（2.24%）抗-HD阳性，其中8例患者血清经酸预处理后，5例HDAg阳性。HDV标志物的总体发生率为3.27%，这反映了北爱尔兰HBsAg携带者（他们属于丁型肝炎的高危人群）中的低感染率。使用酸处理血清以分解抗原/抗体复合物，这在该病毒的鉴定中是一项有用的技术改进。
