Kidd G S, Donowitz M, O'Dorisio T, Cataland S, Newman F
Am J Med. 1979 May;66(5):883-8. doi: 10.1016/0002-9343(79)91147-1.
A 46 year old woman is described who had a 13 half year history of watery diarrhea associated with hypokalemia and hypochlorhydria. The diarrhea was secretory as measured by triple lumen tube perfusion and was associated with an increased concentration of fasting plasma immunoreactive gastric inhibitory polypeptide (GIP) of 750 pg/ml which was stimulated to 4,000 pg/ml after a standard meal. The diarrhea decreased after partial pancreatectomy. Diffuse pancreatic islet cell hyperplasia was present and, although GIP was unmeasureable in the pancreas of normal subjects, it was at least 83 ng/g wet weight in this patient. Postoperatively, the patient's diarrhea responded dramatically to the oral administration of nicotinic acid.
本文描述了一位46岁女性，她有13年半的水样腹泻病史，伴有低钾血症和胃酸过少。通过三腔管灌注测量，腹泻为分泌性，且与空腹血浆免疫反应性胃抑制多肽（GIP）浓度升高有关，基础值为750 pg/ml，标准餐后刺激至4000 pg/ml。部分胰腺切除术后腹泻减轻。存在弥漫性胰岛细胞增生，虽然正常受试者胰腺中无法检测到GIP，但该患者胰腺中GIP含量至少为83 ng/g湿重。术后，患者腹泻对口服烟酸反应显著。
