用于男性性行为和奖励的神经回路。
A neural circuit for male sexual behavior and reward.
机构信息
Departments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Stanford Neurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA.
出版信息
Cell. 2023 Aug 31;186(18):3862-3881.e28. doi: 10.1016/j.cell.2023.07.021. Epub 2023 Aug 11.
Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing innate male sexual behavior and reward remains to be characterized. We have discovered a developmentally wired neural circuit necessary and sufficient for male mating. This circuit connects chemosensory input to BNSTpr neurons, which innervate POA neurons that project to centers regulating motor output and reward. Epistasis studies demonstrate that BNSTpr neurons are upstream of POA neurons, and BNSTpr-released substance P following mate recognition potentiates activation of POA neurons through Tacr1 to initiate mating. Experimental activation of POA neurons triggers mating, even in sexually satiated males, and it is rewarding, eliciting dopamine release and self-stimulation of these cells. Together, we have uncovered a neural circuit that governs the key aspects of innate male sexual behavior: motor displays, drive, and reward.
雄性性行为是天生的和奖励性的。尽管它对生殖至关重要，但控制先天雄性性行为和奖励的分子特异性神经回路仍有待描述。我们已经发现了一个发育性布线的神经回路，它是雄性交配所必需和充分的。这个回路将化学感觉输入连接到 BNSTpr 神经元，BNSTpr 神经元支配投射到调节运动输出和奖励的中枢的 POA 神经元。上位性研究表明，BNSTpr 神经元位于 POA 神经元的上游，并且 BNSTpr 释放的 P 物质在伴侣识别后通过 Tacr1 增强 POA 神经元的激活，从而启动交配。POA 神经元的实验性激活会引发交配，即使是在性满足的雄性中，并且是有奖励的，会引发多巴胺释放和这些细胞的自我刺激。综上所述，我们已经揭示了一个控制先天雄性性行为关键方面的神经回路：运动表现、驱动力和奖励。
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