边缘神经元塑造初次性经历雄性的性识别和社会行为。
Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males.
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
出版信息
Cell. 2019 Feb 21;176(5):1190-1205.e20. doi: 10.1016/j.cell.2018.12.041. Epub 2019 Jan 31.
Sexually naive animals have to distinguish between the sexes because they show species-typical interactions with males and females without meaningful prior experience. However, central neural pathways in naive mammals that recognize sex of other individuals remain poorly characterized. We examined the role of the principal component of the bed nucleus of stria terminalis (BNSTpr), a limbic center, in social interactions in mice. We find that activity of aromatase-expressing BNSTpr (AB) neurons appears to encode sex of other animals and subsequent displays of mating in sexually naive males. Silencing these neurons in males eliminates preference for female pheromones and abrogates mating success, whereas activating them even transiently promotes male-male mating. Surprisingly, female AB neurons do not appear to control sex recognition, mating, or maternal aggression. In summary, AB neurons represent sex of other animals and govern ensuing social behaviors in sexually naive males.
性未成熟的动物必须区分性别，因为它们在没有有意义的先验经验的情况下，表现出与雄性和雌性的物种典型相互作用。然而，在性未成熟的哺乳动物中，识别其他个体性别的中枢神经通路仍未得到很好的描述。我们研究了终纹床核主成分（BNSTpr），一个边缘中心，在小鼠社交互动中的作用。我们发现，表达芳香酶的 BNSTpr（AB）神经元的活动似乎编码了其他动物的性别，以及随后在性未成熟的雄性中展示的交配行为。沉默这些神经元会消除雄性对雌性信息素的偏好，并破坏交配成功，而即使短暂激活它们也会促进雄性间的交配。令人惊讶的是，雌性 AB 神经元似乎不控制性别识别、交配或母性攻击。总之，AB 神经元代表其他动物的性别，并控制性未成熟雄性随后的社交行为。
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