关于“一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验”的评论 - Suppr

A comment on "A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B".

作者信息

Wan Yue-Meng, Wu Hua-Mei, Huang Song-Quan, Li Hua-Yu, Yin Hong-Jing

机构信息

Gastroenterology Department II, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, 650101, China.

Department of Hepatobiliary and Pancreatic Surgery, The Second Afﬁliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China.

出版信息

J Hepatol. 2024 May;80(5):e229-e230. doi: 10.1016/j.jhep.2023.07.038. Epub 2023 Aug 11.

DOI:10.1016/j.jhep.2023.07.038

PMID:37572795

Abstract

摘要

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A comment on "A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B".关于“一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验”的评论

J Hepatol. 2024 May;80(5):e229-e230. doi: 10.1016/j.jhep.2023.07.038. Epub 2023 Aug 11.

Reply to: "A comment on `A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B'".回复：“对‘一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验’的评论”

J Hepatol. 2024 May;80(5):e230-e231. doi: 10.1016/j.jhep.2023.11.034. Epub 2023 Dec 16.

A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B.核苷（酸）类似物停药治疗 HBeAg 阴性慢性乙型肝炎的多中心随机对照临床试验。

J Hepatol. 2023 May;78(5):926-936. doi: 10.1016/j.jhep.2022.12.018. Epub 2023 Mar 28.

Effect on HBs antigen clearance of addition of pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label trial.聚乙二醇干扰素 α-2a 联合核苷（酸）类似物治疗与单独核苷（酸）类似物治疗对 HBeAg 阴性慢性乙型肝炎患者持续不可检测的血浆乙型肝炎病毒 DNA 的影响：一项随机、对照、开放标签试验。

Lancet Gastroenterol Hepatol. 2017 Mar;2(3):177-188. doi: 10.1016/S2468-1253(16)30189-3. Epub 2017 Jan 20.

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B.停止 HBeAg 阴性慢性乙型肝炎核苷（酸）类似物治疗后乙型肝炎病毒特异性 T 细胞应答。

J Hepatol. 2018 Sep;69(3):584-593. doi: 10.1016/j.jhep.2018.05.004. Epub 2018 Jun 29.

Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes.在 HBeAg 血清学转换后停止使用核苷（酸）类似物治疗的高加索乙型肝炎患者，复发率高，结局致命。

Aliment Pharmacol Ther. 2018 Apr;47(8):1170-1180. doi: 10.1111/apt.14560. Epub 2018 Mar 2.

Stopping long-term treatment with nucleos(t)ide analogues is a favourable option for selected patients with HBeAg-negative chronic hepatitis B.对于 HBeAg 阴性慢性乙型肝炎的部分患者，停止长期核苷（酸）类似物治疗是一个有利的选择。

Liver Int. 2018 Feb;38 Suppl 1:90-96. doi: 10.1111/liv.13654.

Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.聚乙二醇干扰素在核苷（酸）类似物时代用于治疗慢性乙型肝炎。

Best Pract Res Clin Gastroenterol. 2008;22(6):1093-108. doi: 10.1016/j.bpg.2008.11.007.

Anti-HBc level predicting virological relapse after stopping nucleos(t)ide analogue in chronic hepatitis B.抗-HBc水平预测慢性乙型肝炎患者停用核苷（酸）类似物后的病毒学复发

Liver Int. 2023 Apr;43(4):947-948. doi: 10.1111/liv.15536. Epub 2023 Feb 17.

Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B.核苷（酸）类似物仅能使大多数慢性乙型肝炎患者的乙型肝炎 e 抗原血清学转换暂时发生。

Gastroenterology. 2010 Aug;139(2):491-8. doi: 10.1053/j.gastro.2010.03.059. Epub 2010 Apr 8.

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A comment on "A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B".

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