回复：“对‘一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验’的评论” - Suppr

Reply to: "A comment on `A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B'".

作者信息

van Bömmel Florian, Berg Thomas

机构信息

Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Liebigstrasse 20, 04103 Leipzig, Germany.

出版信息

J Hepatol. 2024 May;80(5):e230-e231. doi: 10.1016/j.jhep.2023.11.034. Epub 2023 Dec 16.

DOI:10.1016/j.jhep.2023.11.034

PMID:38110010

Abstract

摘要

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Reply to: "A comment on `A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B'".回复：“对‘一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验’的评论”

J Hepatol. 2024 May;80(5):e230-e231. doi: 10.1016/j.jhep.2023.11.034. Epub 2023 Dec 16.

A comment on "A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B".关于“一项关于HBeAg阴性慢性乙型肝炎核苷（酸）类似物停药的多中心随机对照试验”的评论

J Hepatol. 2024 May;80(5):e229-e230. doi: 10.1016/j.jhep.2023.07.038. Epub 2023 Aug 11.

A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B.核苷（酸）类似物停药治疗 HBeAg 阴性慢性乙型肝炎的多中心随机对照临床试验。

J Hepatol. 2023 May;78(5):926-936. doi: 10.1016/j.jhep.2022.12.018. Epub 2023 Mar 28.

Effect on HBs antigen clearance of addition of pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label trial.聚乙二醇干扰素 α-2a 联合核苷（酸）类似物治疗与单独核苷（酸）类似物治疗对 HBeAg 阴性慢性乙型肝炎患者持续不可检测的血浆乙型肝炎病毒 DNA 的影响：一项随机、对照、开放标签试验。

Lancet Gastroenterol Hepatol. 2017 Mar;2(3):177-188. doi: 10.1016/S2468-1253(16)30189-3. Epub 2017 Jan 20.

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B.停止 HBeAg 阴性慢性乙型肝炎核苷（酸）类似物治疗后乙型肝炎病毒特异性 T 细胞应答。

J Hepatol. 2018 Sep;69(3):584-593. doi: 10.1016/j.jhep.2018.05.004. Epub 2018 Jun 29.

Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes.在 HBeAg 血清学转换后停止使用核苷（酸）类似物治疗的高加索乙型肝炎患者，复发率高，结局致命。

Aliment Pharmacol Ther. 2018 Apr;47(8):1170-1180. doi: 10.1111/apt.14560. Epub 2018 Mar 2.

Stopping long-term treatment with nucleos(t)ide analogues is a favourable option for selected patients with HBeAg-negative chronic hepatitis B.对于 HBeAg 阴性慢性乙型肝炎的部分患者，停止长期核苷（酸）类似物治疗是一个有利的选择。

Liver Int. 2018 Feb;38 Suppl 1:90-96. doi: 10.1111/liv.13654.

Systematic review: cessation of long-term nucleos(t)ide analogue therapy in patients with hepatitis B e antigen-negative chronic hepatitis B.系统评价：乙型肝炎e抗原阴性慢性乙型肝炎患者长期核苷（酸）类似物治疗的停药情况

Aliment Pharmacol Ther. 2015 Aug;42(3):243-57. doi: 10.1111/apt.13272. Epub 2015 Jun 10.

Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.聚乙二醇干扰素在核苷（酸）类似物时代用于治疗慢性乙型肝炎。

Best Pract Res Clin Gastroenterol. 2008;22(6):1093-108. doi: 10.1016/j.bpg.2008.11.007.

Anti-HBc level predicting virological relapse after stopping nucleos(t)ide analogue in chronic hepatitis B.抗-HBc水平预测慢性乙型肝炎患者停用核苷（酸）类似物后的病毒学复发

Liver Int. 2023 Apr;43(4):947-948. doi: 10.1111/liv.15536. Epub 2023 Feb 17.

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