School of Public Health and Health Sciences, Amherst, MA, 01003, USA; Department of Environmental Health Sciences, Amherst, MA, 01003, USA; Morrill I, N344, Amherst, MA, 01003, USA; University of Massachusetts, Amherst, MA, 01003, USA.
Retired from Oak Ridge National Laboratory at Oak Ridge, TN, USA.
Chem Biol Interact. 2023 Sep 25;383:110653. doi: 10.1016/j.cbi.2023.110653. Epub 2023 Aug 11.
This paper identifies the occurrence of six major conceptual scientific errors of Hermann Muller and describes how these errors led to the creation of the linear no-threshold (LNT) dose response historically used worldwide for cancer risk assessments for chemical carcinogens and ionizing radiation. The paper demonstrates the significant role that Muller played in the environmental movement, affecting risk assessment policies and practices that are in force even now a half century following his death. This paper lends support to contemporary research that shows significant limitations of the LNT model for cancer risk assessment.
本文指出了赫尔曼·穆勒（Hermann Muller）所犯的六个主要概念性科学错误，并描述了这些错误如何导致了线性无阈（LNT）剂量反应模型的产生，该模型曾被全球用于评估化学致癌物和电离辐射的致癌风险。本文还展示了穆勒在环境运动中所扮演的重要角色，他的观点影响了风险评估政策和实践，即使在他去世半个世纪后的今天，这些政策和实践仍然在发挥作用。本文为当代研究提供了支持，这些研究表明 LNT 模型在癌症风险评估方面存在显著的局限性。
