Fan Heze, Xiong Ying, Huang Yuzhi, Wang Lijun, Xu Chenbo, Li Wenyuan, Feng Xueying, Yang Yuxuan, Hua Rui, Wang Zihao, Yuan Zuyi, Zhou Juan
Cardiovascular Department, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an 710061, China.
Cardiovascular Department, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an 710061, China.
Sci Total Environ. 2023 Dec 10;903:166234. doi: 10.1016/j.scitotenv.2023.166234. Epub 2023 Aug 11.
Selenium (Se) has been reported to have an antagonistic effect on heavy metals in animals. However, there is no epidemiological study investigating whether Se could protect against the pulmonary toxicity of Cadmium (Cd) and Lead (Pb). Data was collected from the 2011-2012 National Health and Nutrition Examination Survey (NHANES) cycle. Pulmonary function was assessed by Forced Vital Capacity (FVC), Forced Expiratory Volume 1st Second (FEV) and FEV/FVC. Blood concentrations of Cd, Pb, and Se were measured using inductively coupled plasma mass spectrometry. Linear regression, restricted cubic splines, and quantile-based g-computation (qgcomp) were performed to evaluate the individual and joint associations of Cd and Pb with pulmonary function and whether Se modified these associations. In the adjusted multi-metal model, every 1-unit increase in Cd, FEV, FVC, and FEV/FVC decreased by 76.437 mL (95 % CI: -110.928 to -41.947), 42.719 mL (95 % CI: -84.553 to -0.885), and 0.012 (95 % CI: -0.016 to -0.007), respectively. Meanwhile, FEV decreased by 9.37 mL (95 % CI: -18.61 to -0.13) for every 1 unit increase in Pb. Furthermore, we found an inverted U-shape association between Se and lung function, and participants in the second quartile Se group had the highest increases in FEV and FVC compared with participants in the lowest quartile. Qgcomp model also revealed that the toxic metal mixture (Cd and Pb) exhibited a significant inverse association with FEV and FEV/FVC. Furthermore, we found that the inverse association of Pb and Cd, either alone or in combination, with pulmonary function first diminished with increasing Se levels but was re-enforced when blood Se concentrations were in the highest quartile. Our results indicated that moderate Se attenuated the harmful effects of Cd and Pb on lung function.
据报道，硒（Se）对动物体内的重金属具有拮抗作用。然而，尚无流行病学研究调查硒是否能预防镉（Cd）和铅（Pb）的肺毒性。数据收集自2011 - 2012年国家健康与营养检查调查（NHANES）周期。通过用力肺活量（FVC）、第1秒用力呼气量（FEV）和FEV/FVC评估肺功能。使用电感耦合等离子体质谱法测量血液中镉、铅和硒的浓度。进行线性回归、受限立方样条和基于分位数的g计算（qgcomp），以评估镉和铅与肺功能的个体和联合关联，以及硒是否改变了这些关联。在调整后的多金属模型中，镉每增加1个单位，FEV、FVC和FEV/FVC分别下降76.437毫升（95%置信区间：-110.928至-41.947）、42.719毫升（95%置信区间：-84.553至-0.885）和0.012（95%置信区间：-0.016至-0.007）。同时，铅每增加1个单位，FEV下降9.37毫升（95%置信区间：-18.61至-0.13）。此外，我们发现硒与肺功能之间存在倒U形关联，与最低四分位数组的参与者相比，第二四分位数硒组的参与者FEV和FVC增加最多。Qgcomp模型还显示，有毒金属混合物（镉和铅）与FEV和FEV/FVC呈显著负相关。此外，我们发现，铅和镉单独或联合与肺功能的负相关首先随着硒水平的升高而减弱，但当血液硒浓度处于最高四分位数时又会增强。我们的结果表明，适量的硒可减轻镉和铅对肺功能的有害影响。
