Jiang Hejun, Yang Guijun, Chen Jing, Yuan Shuhua, Wu Jinhong, Zhang Jing, Zhang Lei, Yuan Jiajun, Lin Jilei, Chen Jiande, Yin Yong
Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Respiratory Medicine, Linyi Maternal and Child Healthcare Hospital, Linyi Branch of Shanghai Children's Medical Center, Shanghai JiaoTong University School of Medicine, Linyi, Shandong, China.
Front Nutr. 2024 May 17;11:1362119. doi: 10.3389/fnut.2024.1362119. eCollection 2024.
This study aimed to examine the correlation between selenium intake and lung function in asthmatic people.
A total of 4,541 individuals in the US National Health and Nutrition Examination Survey (NHANES) were included in this study. Multivariate linear regression, variance inflation factor, restricted cubic splines and quantile regression were used to analyze the relationship between Se intake and lung function. We divided selenium intake into four levels based on quartiles: Q1: Se ≤ 76.75 mcg/d; Q2: 76.75-105.1 mcg/d; Q3: 105.1-137.65 mcg/d; and Q4: Se ≥137.65 mcg/d.
Asthma was negatively associated with the Ratio of Forced Expiratory Volume 1st Second to Forced Vital Capacity (FEV1/FVC) (β = -0.04, 95% CI: -0.06 to -0.02) and FEV1 (β = -215, 95% CI: -340 to -90). Se intake was positively associated with Forced Expiratory Volume 1st Second (FEV1) (β =3.30 95% CI: 2.60 to 4.00) and Forced Vital Capacity (FVC) (β =4.30, 95% CI: 3.50 to 5.10). In asthmatic individuals, the positive effects of Se intake on FVC were enhanced with increasing Se intake, while the positive effects of Se intake on FEV1 varied less dramatically. High Se intake (Q4 level, above 137.65 mcg/d) improved FVC (β = 353, 95% CI: 80 to 626) and FEV1 (β = 543, 95% CI: 118 to 969) in asthmatic patients compared to low Se intake (Q1 level, below 76.75 mcg/d). At the Q2 level (76.75-105.1 mcg/d) and Q4 level (Se ≥137.65 mcg/d) of Se intake, the correlation between FEV1 and asthma disappeared.
Our research has revealed a positive correlation between selenium intake and lung function in asthma patients and the strength of this positive correlation is related to the amount of selenium intake. We recommend that asthma patients consume 137.65 mcg to 200 mcg of selenium daily to improve pulmonary function while avoiding the adverse effects of selenium on the human body.
本研究旨在探讨哮喘患者硒摄入量与肺功能之间的相关性。
美国国家健康与营养检查调查（NHANES）中的4541名个体纳入本研究。采用多元线性回归、方差膨胀因子、受限立方样条和分位数回归分析硒摄入量与肺功能之间的关系。我们根据四分位数将硒摄入量分为四个水平：Q1：硒≤76.75微克/天；Q2：76.75 - 105.1微克/天；Q3：105.1 - 137.65微克/天；Q4：硒≥137.65微克/天。
哮喘与第一秒用力呼气量与用力肺活量之比（FEV1/FVC）呈负相关（β = -0.04，95%置信区间：-0.06至-0.02）以及与FEV1呈负相关（β = -215，95%置信区间：-340至-90）。硒摄入量与第一秒用力呼气量（FEV1）呈正相关（β = 3.30，95%置信区间：2.60至4.00）以及与用力肺活量（FVC）呈正相关（β = 4.30，95%置信区间：3.50至5.10）。在哮喘个体中，硒摄入量对FVC的积极作用随硒摄入量增加而增强，而硒摄入量对FEV1的积极作用变化不那么显著。与低硒摄入量（Q1水平，低于76.75微克/天）相比，高硒摄入量（Q4水平，高于137.65微克/天）改善了哮喘患者的FVC（β = 353，95%置信区间：80至626）和FEV1（β = 543，95%置信区间：118至969）。在硒摄入量的Q2水平（76.75 - 105.1微克/天）和Q4水平（硒≥137.65微克/天）时，FEV1与哮喘之间的相关性消失。
我们的研究揭示了哮喘患者硒摄入量与肺功能之间存在正相关，且这种正相关的强度与硒摄入量有关。我们建议哮喘患者每天摄入137.65微克至200微克的硒以改善肺功能，同时避免硒对人体的不良影响。
