Battler A, Lieberman D, Rath S, Rotstein Z, Rabinowitz B, Neufeld H N
Clin Cardiol. 1986 Sep;9(9):431-5. doi: 10.1002/clc.4960090909.
The effect of metoprolol on global left ventricular function during exercise was analyzed with nuclear ventriculography in 17 patients with ischemic heart disease. All had stable angina pectoris and ST-segment depression of more than 0.1 mV during treadmill exercise when not taking metoprolol. Each patient was stressed with supine bicycle exercise to the same load on a maintenance dose of metoprolol (100 mg X 2/day) and on a second occasion without the drug, the two being separated by 7 days. The mean heart rate and systolic blood pressure were significantly reduced both at rest and exercise with metoprolol. There was no significant difference of rest left ventricular ejection fraction with or without metoprolol. At exercise, however, every patient showed improvement of left ventricular function, the average left ventricular ejection fraction increasing by 14% (+/- 6) relative to the same exercise without metoprolol (p less than 0.001). We conclude that chronic metoprolol treatment in patients with ischemic heart disease can ameliorate left ventricular dysfunction induced by exercise and may thereby reduce myocardial ischemia.
应用核素心室造影术对17例缺血性心脏病患者运动期间美托洛尔对左心室整体功能的影响进行了分析。所有患者均患有稳定型心绞痛，在未服用美托洛尔时，平板运动期间ST段压低超过0.1mV。每位患者在服用美托洛尔维持剂量（100mg×2/日）时，通过仰卧位自行车运动达到相同负荷进行负荷试验，另一次在不服药情况下进行，两次试验间隔7天。服用美托洛尔时，静息和运动时的平均心率和收缩压均显著降低。服用或未服用美托洛尔时静息左心室射血分数无显著差异。然而，在运动时，每位患者的左心室功能均有改善，相对于未服用美托洛尔时的相同运动，平均左心室射血分数增加了14%（±6）（p<0.001）。我们得出结论，缺血性心脏病患者长期服用美托洛尔可改善运动诱发的左心室功能障碍，从而可能减少心肌缺血。
