Department of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates.
Department of Rheumatology, Sheikh Shakhbout Medical City (SSMC), P.O. Box 11001, Abu Dhabi, United Arab Emirates.
BMC Public Health. 2023 Aug 12;23(1):1542. doi: 10.1186/s12889-023-16490-1.
To assess osteoarthritis (OA) patients' preferences for pharmaceutical treatment via Adaptive Choice-Based Conjoint (ACBC) method.
A United Arab Emirates (UAE) based Patient and Public Involvement (PPI) group designed the ACBC questionnaire with 10 attributes and 34 levels. The questionnaire was developed using Sawtooth Software and analyzed through Hierarchical Bayesian (HB). Results were standardized using Z-score via SPSS.
Study participants were 1030 OA patients, 83.6% aged 50 or older and 83.4% female. The avoidance of medication's side effects accounted for 66% relative importance compared to 6% relative importance for the medication's benefits. The "way of taking the medicine" attribute had the highest coefficient of variation (70%) and the four side effect attributes "risk of gastric ulcer, addiction, kidney and liver impairment, and heart attacks and strokes" had a coefficient of variation from 18 to 21%.
Arab OA patients are similar to other ethnic groups in trading-off benefits and side effects and consistently prioritizing the avoidance of medications' side effects. Although the "Way of taking medicine" was the least important attribute it was associated with the highest variation amongst patients. OA patients also prefer prescribed medications to internet-purchased and over-the-counter options.
通过适应性选择基础联合分析（ACBC）方法评估骨关节炎（OA）患者对药物治疗的偏好。
阿联酋（UAE）患者和公众参与（PPI）小组设计了 ACBC 问卷，其中包含 10 个属性和 34 个水平。该问卷使用 Sawtooth 软件开发，并通过分层贝叶斯（HB）进行分析。结果通过 SPSS 中的 Z 分数进行标准化。
研究参与者为 1030 名 OA 患者，其中 66%的年龄在 50 岁或以上，83.4%为女性。与药物益处的 6%相对重要性相比，避免药物副作用的相对重要性占 66%。“服药方式”属性的变异系数最高（70%），四个副作用属性“胃溃疡风险、成瘾、肾肝损伤以及心脏病发作和中风”的变异系数为 18 到 21%。
阿拉伯 OA 患者在权衡利弊和副作用方面与其他种族群体相似，始终优先考虑避免药物副作用。尽管“服药方式”是最不重要的属性，但它与患者之间的最大差异相关。OA 患者也更喜欢处方药物，而不是互联网购买和非处方选择。
