Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
Ann Parasitol. 2022;68(4):685-692. doi: 10.17420/ap6804.475.
Toxoplasma gondii is an obligate intracellular protozoan parasite; it spreads via the circulatory system during infection and causes chronic infection in various organs. Toxoplasmosis affects nearly one third of people worldwide, especially immunocompromised people. This study aimed to determine the effect of toxoplasmosis on renal function in hemodialysis patients. Overall 300 patients referred to the Medical City, Al-Karama General Hospital, Baghdad, Iraq were enrolled from 2021 to 2022. All serum samples were tested for T. gondii immunoglobulins (IgG and IgM) antibodies, urea and creatinine levels. In patients undergoing hemodialysis, the results revealed a high positivity percentage for anti-Toxoplasma IgG. In hemodialysis patients infected with T. gondii, the urea and creatinine levels were higher than the controls. The mean urea level was high in hemodialysis patients infected with toxoplasmosis compare with hemodialysis patient without toxoplasmosis in different gender and age while the level of creatinine had no significant differences in hemodialysis patient with or without toxoplasmosis. These finding suggest that the incidental rate of toxoplasmosis could be considered as an indication to the high risk of hemodialysis patients.
刚地弓形虫是一种专性细胞内寄生的原虫，它在感染过程中通过循环系统传播，并在各种器官中引起慢性感染。全世界近三分之一的人感染弓形虫，尤其是免疫功能低下的人。本研究旨在确定弓形虫病对血液透析患者肾功能的影响。2021 年至 2022 年，从伊拉克巴格达 Al-Karama 总医院医学城招募了 300 名患者。所有血清样本均检测了弓形体免疫球蛋白（IgG 和 IgM）抗体、尿素和肌酐水平。在接受血液透析的患者中，抗弓形体 IgG 的阳性率较高。感染弓形体的血液透析患者的尿素和肌酐水平高于对照组。与未感染弓形体的血液透析患者相比，感染弓形体的血液透析患者的平均尿素水平较高，而不同性别和年龄的血液透析患者的肌酐水平无显著差异。这些发现表明，偶然感染弓形体的发生率可能被认为是血液透析患者高风险的一个指标。
