免疫细胞亚群和血清神经丝轻链与多发性硬化症疾病恶化风险增加相关。
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis.
机构信息
Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
出版信息
J Neuroimmunol. 2023 Sep 15;382:578175. doi: 10.1016/j.jneuroim.2023.578175. Epub 2023 Aug 7.
Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.
外周血淋巴细胞亚群的变化已被提议作为多发性硬化症（MS）疾病活动评估的生物标志物。血清神经丝轻链（sNfL）是一种反映 MS 神经轴突损伤的生物标志物，可用于监测疾病活动、药物反应和预测疾病进程。在这里，我们显示 sNfL 与淋巴细胞细胞亚群之间存在中度相关性，并且我们的数据进一步表明，sNfL 和特定的免疫细胞亚群一起可以预测 MS 未来的疾病恶化。
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