Du Mingyu, Yang Yuan, Zhang Lin
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, No.37 Xueyuan Road, Haidian District, Beijing, China; Key Laboratory of Big Data-Based Precision Medicine, Ministry of Industry and Information Technology, No.37 Xueyuan Road, Haidian District, Beijing, China; School of Automation Science and Electrical Engineering, Beihang University, No.37 Xueyuan Road, Haidian District, Beijing, China.
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, No.37 Xueyuan Road, Haidian District, Beijing, China; Key Laboratory of Big Data-Based Precision Medicine, Ministry of Industry and Information Technology, No.37 Xueyuan Road, Haidian District, Beijing, China; School of Automation Science and Electrical Engineering, Beihang University, No.37 Xueyuan Road, Haidian District, Beijing, China.
Comput Biol Med. 2023 Sep;164:107275. doi: 10.1016/j.compbiomed.2023.107275. Epub 2023 Aug 9.
In recent years, the proportion of the elderly in the society is continuously increasing. Cardiovascular disease is a big problem that puzzles the health of the elderly. Among them, atrial fibrillation is one of the most common arrhythmia diseases in recent years, which poses a great threat to human life safety. At the same time, deep learning has become a powerful tool for medical and healthcare applications due to its high accuracy and fast detection speed. The diagnosis of atrial fibrillation is based on electrocardiogram, ECG) timing signals. At present, the scale of the open ECG data set is limited, and a large amount of labeled ECG data is needed to build a high-precision diagnostic model. In this study, a two-channel network model and a feature queue technique are proposed. A high-quality classification diagnosis model of atrial fibrillation is obtained by unsupervised domain adaptive technique, which uses a small amount of labeled data and a large amount of unlabeled data for training. The research content of this paper includes the following aspects: 1) Build a dual-channel network model, which can analyze ECG signals from different feature dimensions. At the same time, the dual-channel output also improves the reliability of the model's pseudo-label in the adaptive training stage and the accuracy of the output in the testing stage. 2) Innovative feature queue technology including global centroid is proposed to participate in the process of domain discrepancy metric calculation, which can use a small amount of labeled data and a large amount of unlabeled data to achieve a more stable and rapid update of the network. 3) Improved and innovated the domain discrepancy metric function, and introduced an evaluation formula for the credibility of false labels to improve the learning efficiency of unlabeled data. Finally, the experimental results show that the proposed two-channel network model and the feature queue technique with global centroid can achieve a high generalization and high precision depth network model by training with a small amount of labeled data and a large amount of unlabeled data. 4) The proposed model achieved a precision of 95.12%, a recall of 95.36%, an accuracy of 98.05%, and an F1 score of 95.23% in the MIT-BIH Arrhythmia Database. In the MIT-BIH Atrial Fibrillation Database, the model achieved a precision of 98.9%, a recall of 99.03%, an accuracy of 99.13%, and an F1 score of 99.08%.
近年来,社会中老年人口的比例在不断增加。心血管疾病是困扰老年人健康的一大问题。其中,心房颤动是近年来最常见的心律失常疾病之一,对人类生命安全构成巨大威胁。同时,深度学习因其高精度和快速检测速度,已成为医疗保健应用的强大工具。心房颤动的诊断基于心电图(ECG)定时信号。目前,公开的心电图数据集规模有限,需要大量带标签的心电图数据来构建高精度的诊断模型。在本研究中,提出了一种双通道网络模型和一种特征队列技术。通过无监督域自适应技术获得了高质量的心房颤动分类诊断模型,该技术使用少量带标签数据和大量无标签数据进行训练。本文的研究内容包括以下几个方面:1)构建双通道网络模型,该模型可以从不同特征维度分析心电图信号。同时,双通道输出也提高了模型在自适应训练阶段伪标签的可靠性以及测试阶段输出的准确性。2)提出了包括全局质心在内的创新特征队列技术,参与域差异度量计算过程,该技术可以使用少量带标签数据和大量无标签数据实现网络更稳定、快速的更新。3)改进并创新了域差异度量函数,引入了伪标签可信度评估公式以提高无标签数据的学习效率。最后实验结果表明,所提出的双通道网络模型和带有全局质心的特征队列技术,通过使用少量带标签数据和大量无标签数据进行训练,可以实现高泛化性和高精度的深度网络模型。4)所提出的模型在麻省理工学院 - 贝斯以色列女执事医疗中心心律失常数据库(MIT - BIH Arrhythmia Database)中实现了精确率为95.12%、召回率为95.36%、准确率为98.05%以及F1分数为95.23%。在麻省理工学院 - 贝斯以色列女执事医疗中心心房颤动数据库(MIT - BIH Atrial Fibrillation Database)中,该模型实现了精确率为98.9%、召回率为99.03%、准确率为99.13%以及F1分数为99.08%。