Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, Turkey.
Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Semin Arthritis Rheum. 2023 Oct;62:152246. doi: 10.1016/j.semarthrit.2023.152246. Epub 2023 Aug 9.
Behçet's Disease (BD) is a chronic multisystem vasculitis that manifests with destructive inflammation affecting the eyes, central nervous system, and blood vessels. The pathology of vein involvement in BD is poorly characterized. Magnetic resonance (MR) venography gives more comprehensive information about deep veins and adjacent tissues. In this study, we aimed to characterize vein involvement and evaluate the diagnostic utility of MR venography in BD.
Sixty-five BD patients who fulfilled the International Study Group (ISG) criteria and 20 healthy control subjects were enrolled. Inferior vena cava (IVC), common iliac veins (CIV), external (EIV) and internal iliac veins (IVV), common femoral veins (CFV), femoral veins (FV), and greater saphenous veins (GSV) of BD patients and healthy controls were evaluated with MR venography and ultrasonography for the presence pathologic features, luminal thrombi, vessel wall changes, and perivascular abnormalities.
33 vascular and 32 non-vascular BD patients (mean age 39.3 ± 11.3 years and 48 [73.8%] male) were enrolled. MR venography revealed diffuse concentric thickening of the walls of IVC, CIV, EIV, IIV, CFV, FV, and GSV in BD (healthy controls vs. BD p<0.05 for all vein segments). MR venography provided additional information about veins and perivascular tissues like contrast enhancement, enlarged lymph nodes, and seminal vesicle vascularization, which were remarkably more frequent in vascular BD than non-vascular BD and healthy controls.
The results of our study suggest that the involvement of the venous system is diffuse and generalized in BD, and demonstration of venulitis might help diagnose the disease.
贝赫切特病（BD）是一种慢性多系统血管炎，表现为影响眼睛、中枢神经系统和血管的破坏性炎症。BD 静脉受累的病理学特征描述较少。磁共振（MR）静脉造影可提供关于深静脉和邻近组织的更全面信息。本研究旨在描述静脉受累情况，并评估 MR 静脉造影在 BD 中的诊断价值。
本研究纳入了 65 例符合国际研究组（ISG）标准的 BD 患者和 20 名健康对照者。使用 MR 静脉造影和超声检查评估 BD 患者和健康对照者的下腔静脉（IVC）、髂总静脉（CIV）、外髂静脉（EIV）和内髂静脉（IVV）、股总静脉（CFV）、股静脉（FV）和大隐静脉（GSV）的病理性特征、管腔内血栓、血管壁变化和血管周围异常。
本研究纳入了 33 例血管性和 32 例非血管性 BD 患者（平均年龄 39.3±11.3 岁，48 例[73.8%]为男性）。MR 静脉造影显示 IVC、CIV、EIV、IVV、CFV、FV 和 GSV 的血管壁呈弥漫性、同心性增厚（所有静脉节段与健康对照组相比，p<0.05）。MR 静脉造影提供了关于静脉和血管周围组织的额外信息，如对比增强、增大的淋巴结和精囊血管化，这些在血管性 BD 中比非血管性 BD 和健康对照组更为常见。
本研究结果表明，BD 患者的静脉系统受累广泛且弥漫，静脉炎的表现可能有助于诊断该疾病。
