Karadeniz Hazan, Mammadov Tunjay, Cerit Mahi Nur, Kardas Rıza Can, Guler Aslıhan Avanoglu, Yıldırım Derya, Vasi Ibrahim, Pasaoglu Hatice, Erden Abdulsamet, Kucuk Hamit, Goker Berna, Ozturk Mehmet Akif, Tufan Abdurrahman
Division of Rheumatology, GülhaneTraining and Research Hospital, Ankara, Turkey.
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ir J Med Sci. 2025 Jun 12. doi: 10.1007/s11845-025-03972-x.
The study aims to evaluate the relationship between prothrombotic soluble serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and the thickness measurements of the carotid artery, femoral, portal, and jugular veins in patients with Behçet's disease (BD).
Fifty-six BD patients who met the International Study Group criteria and 19 healthy control subjects were enrolled. We compared the groups' differences in B-mode ultrasound findings and biochemical prothrombotic markers. Logistic regression was used to analyze independent factors influencing thrombosis, and a receiver operating characteristic curve was plotted.
A total of 34 non-vascular and 22 vascular BD patients (mean age 41.5 ± 11.8 years, 38 (67.9%) male) were included in the study. No significant differences were observed between patients and healthy controls (HCs) in terms of sex, age, and body mass index. BD patients had elevated serum levels of P-selectin, CitH3, and GDF-15 compared to HCs (p < 0.05). CitH3 and GDF-15 levels were significantly higher in BD patients with vascular involvement than those without vascular disease (p < 0.05). The GDF-15 level in vascular BD patients showed a significant correlation with femoral vein thickness.
GDF-15 and CitH3 are potential biomarkers that show vascular involvement and thrombosis in BD.
本研究旨在评估白塞病（BD）患者促血栓形成的可溶性血清P选择素、瓜氨酸化组蛋白H3（CitH3）和生长分化因子15（GDF-15）水平与颈动脉、股静脉、门静脉和颈静脉厚度测量值之间的关系。
纳入56例符合国际研究组标准的BD患者和19例健康对照者。我们比较了两组在B型超声检查结果和生化促血栓形成标志物方面的差异。采用逻辑回归分析影响血栓形成的独立因素，并绘制受试者工作特征曲线。
本研究共纳入34例非血管性BD患者和22例血管性BD患者（平均年龄41.5±11.8岁，38例（67.9%）为男性）。患者与健康对照者在性别、年龄和体重指数方面无显著差异。与健康对照者相比，BD患者血清P选择素、CitH3和GDF-15水平升高（p<0.05）。血管受累的BD患者CitH3和GDF-15水平显著高于无血管疾病的患者（p<0.05）。血管性BD患者的GDF-15水平与股静脉厚度显著相关。
GDF-15和CitH3是显示BD血管受累和血栓形成的潜在生物标志物。
