Leicester School of Pharmacy, De Montfort University, Leicester, UK.
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Drug Discov Today. 2023 Oct;28(10):103735. doi: 10.1016/j.drudis.2023.103735. Epub 2023 Aug 11.
The blood-brain barrier (BBB) is a protective element of the neurovascular unit (NVU) surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex, which play a fundamental role in brain homeostasis. Due to its impeccable structural architecture, the BBB is referred to as the brain's gatekeeper, a near-impenetrable barrier to therapeutics. This review summarises the significant strides that have been made in the last 5 years towards circumventing the BBB and developing efficient drug delivery systems. Challenges associated with several CNS disorders related to BBB failure and exploitation of this unique NVU component for targeted treatment of brain-related disorders are also discussed.
血脑屏障（BBB）是神经血管单元（NVU）的保护元件，由星形胶质细胞、周细胞、细胞外基质和紧密连接复合体环绕，在脑内稳态中发挥着重要作用。由于其完美的结构架构，BBB 被称为大脑的守门员，是治疗药物难以穿透的屏障。本综述总结了过去 5 年来在克服 BBB 并开发高效药物递送系统方面取得的重大进展。还讨论了与 BBB 失败相关的几种中枢神经系统疾病以及利用这一独特的 NVU 成分靶向治疗与大脑相关疾病所面临的挑战。
