Jin N N, Chen X W, Gu Y Q, Wang H L, Zhang Q, Liu L, Niu K J
Clinical Nutrition Department and geriatric Medicine Department, Tianjin Binhai People's Hospital, Tianjin 300280, China.
School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China Nutritional Epidemiology Institute, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Aug 6;57(8):1186-1193. doi: 10.3760/cma.j.cn112150-20230210-00094.
To evaluate the association between immunoglobulin concentration and the risk of type 2 diabetes mellitus (T2DM) in adults in Tianjin City. Based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIHealth) cohort from January 2010 to December 2018, subjects who had completed the measurement of baseline immunoglobulin concentration and blood glucose concentration and not been diagnosed with any type of diabetes at baseline were selected in this study. The collected data included the concentration of serum immunoglobulin (IgG, IgM, IgA and IgE), fasting blood glucose and other potential confounders. The subjects were divided into four groups from to according to the quartiles of baseline immunoglobulin concentration. The multivariable Cox regression model was used to assess the association between the baseline immunoglobulin concentration and T2DM. A total of 6 315 subjects aged (50.1±10.0) years were included. About 390 subjects were newly diagnosed with T2DM during the follow-up period. The incidence rate was 16.8/1 000 person-years. After adjusting for age, sex, waist circumference, smoking status, drinking status, eosinophil ratio, metabolic syndrome, first-or second-degree family history, and reciprocal adjusting for other immunoglobulin concentrations, compared to the lowest quartile concentration group , subjects in group with the highest quartile of IgG concentration showed a lower risk of T2DM (=0.71, 95%: 0.52-0.97), and subjects in group with the highest quartile of IgM concentration also had a decreased risk of T2DM (=0.66, 95%: 0.47-0.91). Subjects in group with the highest quartile of IgA concentration had an increased risk of T2DM (=1.56, 95%: 1.18-2.07). The risk of T2DM decreased with the increase of serum IgG and IgM concentrations (=0.018, =0.010) and increased with the increase of serum IgA concentrations (<0.001). No association was found between the concentration of IgE and T2DM risk (=0.99, 95%: 0.74-1.31, =0.891). The concentration of IgG and IgM is negatively associated with the risk of T2DM, and the concentration of IgA is positively associated with the risk of T2DM in Tianjin City. The concentrations of IgG, IgM and IgA could be a predictor of hyperglycemia and T2DM.
评估天津市成年人免疫球蛋白浓度与2型糖尿病（T2DM）风险之间的关联。基于2010年1月至2018年12月的天津慢性低度全身炎症与健康（TCLSIHealth）队列，本研究选取了完成基线免疫球蛋白浓度和血糖浓度测量且在基线时未被诊断为任何类型糖尿病的受试者。收集的数据包括血清免疫球蛋白（IgG、IgM、IgA和IgE）浓度、空腹血糖及其他潜在混杂因素。根据基线免疫球蛋白浓度的四分位数将受试者分为四组。采用多变量Cox回归模型评估基线免疫球蛋白浓度与T2DM之间的关联。共纳入6315名年龄为（50.1±10.0）岁的受试者。随访期间约390名受试者新诊断为T2DM。发病率为16.8/1000人年。在调整年龄、性别、腰围、吸烟状况、饮酒状况、嗜酸性粒细胞比例、代谢综合征、一级或二级家族史，并对其他免疫球蛋白浓度进行相互调整后，与最低四分位数浓度组相比，IgG浓度最高四分位数的组2受试者患T2DM的风险较低（HR = 0.71，95%CI：0.52 - 0.97），IgM浓度最高四分位数的组3受试者患T2DM的风险也降低（HR = 0.66，95%CI：0.47 - 0.91）。IgA浓度最高四分位数的组4受试者患T2DM的风险增加（HR = 1.56，95%CI：1.18 - 2.07）。T2DM风险随血清IgG和IgM浓度升高而降低（P = 0.018，P = 0.010），随血清IgA浓度升高而增加（P < 0.001）。未发现IgE浓度与T2DM风险之间存在关联（HR = 0.99，95%CI：0.74 - 1.31，P = 0.891）。在天津市，IgG和IgM浓度与T2DM风险呈负相关，IgA浓度与T2DM风险呈正相关。IgG、IgM和IgA浓度可能是高血糖和T2DM的预测指标。
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