Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China; Clinical Research Center for Mental Disorders, School of Medicine, Tongji University, Shanghai, China.
Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China; Clinical Research Center for Mental Disorders, School of Medicine, Tongji University, Shanghai, China.
Psychiatry Res. 2023 Sep;327:115411. doi: 10.1016/j.psychres.2023.115411. Epub 2023 Aug 11.
Prior studies indicate that subjects undergoing methadone maintenance therapy (MMT) may experience anxiety, depression and cravings. This study aimed to explore the impact of intermittent theta burst stimulation (iTBS)-MMT combination on craving and emotional symptoms of opioid use disorder. This comparative study included subjects with opioid use disorder at the Methadone Maintenance Clinic of Pudong New Area between September 2019 and March 2020. The subjects were divided into two groups: those who received iTBS-MMT combination treatment (iTBS-MMT) and those who received MMT treatment and sham stimulation treatment (MMT). Outcomes were reduction rate of anxiety, depression and craving. Anxiety was measured by Hamilton Anxiety (HAMA) scale, depression was determined by Hamilton Depression (HAMD) scale and craving was analyzed using visual analog scale. A total of 76 subjects completed the treatment, with 38 subjects in each group. Twenty days after treatment, subjects in the iTBS-MMT group had significant improvement of anxiety (HAMA reduction rate), depression (HAMD reduction rate) and craving (Craving reduction rate) reduction rate compared with MMT group. iTBS-MMT combination treatment may produce better drug craving reduction and emotional improvement than MMT alone.
先前的研究表明，接受美沙酮维持治疗（MMT）的患者可能会出现焦虑、抑郁和渴望等症状。本研究旨在探讨间歇性经颅磁刺激（iTBS）-MMT 联合治疗对阿片类药物使用障碍患者的渴望和情绪症状的影响。这项对比研究纳入了 2019 年 9 月至 2020 年 3 月在浦东新区美沙酮维持治疗诊所就诊的阿片类药物使用障碍患者。将患者分为两组：接受 iTBS-MMT 联合治疗（iTBS-MMT）的患者和接受 MMT 治疗和假刺激治疗（MMT）的患者。结果为焦虑、抑郁和渴望的降低率。焦虑采用汉密尔顿焦虑量表（HAMA）评定，抑郁采用汉密尔顿抑郁量表（HAMD）评定，渴望采用视觉模拟评分法（VAS）进行分析。共有 76 例患者完成了治疗，每组 38 例。治疗 20 天后，iTBS-MMT 组患者的焦虑（HAMA 降低率）、抑郁（HAMD 降低率）和渴望（渴望降低率）改善程度明显优于 MMT 组。与单独 MMT 相比，iTBS-MMT 联合治疗可能产生更好的药物渴望减轻和情绪改善。
