用于阿片类物质使用障碍的无创脑刺激：文献综述
Noninvasive Brain Stimulation for Opioid Use Disorder: An Update of the Literature.
作者信息
Blyth Sophia H, Polick Carri, Kim Lena, Eason Sonya, Rubenstein Dana, Thompson Suzanna, Drummond Trevor, Ward Heather Burrell, Young Jonathan R
机构信息
Department of Psychiatry and Behavioral Science, Vanderbilt University Medical Center, Nashville, TN.
Duke University School of Nursing, Durham, NC.
出版信息
Curr Behav Neurosci Rep. 2025;12(1). doi: 10.1007/s40473-024-00293-8. Epub 2025 Feb 3.
PURPOSE OF REVIEW
Although medications for opioid use disorder (OUD) are effective, relapse remains common. Noninvasive brain stimulation (NIBS) has emerged as a potential adjunctive treatment. We review publications since 2020 that tested NIBS interventions in humans and assessed clinically relevant outcomes.
RECENT FINDINGS
We identified a total of 19 studies of NIBS for treatment of craving; acute detoxification, withdrawal, and early abstinence; relapse prevention; cognitive dysfunction associated with OUD; mood and anxiety symptoms in OUD; co-occurring SUDs with OUD; and post-operative pain management and prevention of OUD.
SUMMARY
NIBS interventions, particularly repetitive transcranial magnetic stimulation and transcranial direct current stimulation have demonstrated preliminary evidence of effectiveness to treat OUD and its associated symptoms.
综述目的
尽管用于阿片类物质使用障碍（OUD）的药物有效，但复发仍然很常见。非侵入性脑刺激（NIBS）已成为一种潜在的辅助治疗方法。我们回顾了自2020年以来测试NIBS干预措施对人类影响并评估临床相关结果的出版物。
最新发现
我们总共确定了19项关于NIBS治疗渴望、急性脱毒、戒断和早期戒断、预防复发、与OUD相关的认知功能障碍、OUD中的情绪和焦虑症状、与OUD共病的物质使用障碍以及术后疼痛管理和预防OUD的研究。
总结
NIBS干预措施，特别是重复经颅磁刺激和经颅直流电刺激，已显示出治疗OUD及其相关症状有效性的初步证据。
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