Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Institute of Clinical Pharmacy, Central South University, Changsha, China.
Nat Prod Res. 2024 Oct;38(19):3329-3335. doi: 10.1080/14786419.2023.2246630. Epub 2023 Aug 13.
Aimed to explore the mechanisms and targets of Diwu Yanggan Capsule (DWYG), a traditional Chinese medicine in liver regeneration, we used the TCMSP to obtain the active ingredients and targets of DWYG and the GEO database to obtain the DEGs related to liver regeneration. We also searched for liver regeneration-related genes in disease databases and integrated them with the herbal and GEO data to screen for potential targets of DWYG in liver regeneration. Enrichment analysis using R language and molecular docking of the key targets and active ingredients were constructed. We found 73 potential targets of DWYG in liver regeneration and revealed that DWYG may act through pathways such as MAPK, TNF, and IL-17. We also found that quercetin was a major component of DWYG with low binding energy to three key targets. Our results suggest that DWYG can facilitate liver regeneration and quercetin may be its core ingredient.
探索中药地乌龟胶囊（DWYG）在肝再生中的作用机制和靶点。方法：利用 TCMSP 数据库获取 DWYG 的活性成分和靶点，利用 GEO 数据库获取与肝再生相关的 DEGs。从疾病数据库中搜索肝再生相关基因，并将其与草药和 GEO 数据整合，筛选 DWYG 在肝再生中的潜在靶点。利用 R 语言进行富集分析，并构建关键靶点和活性成分的分子对接。结果：发现 73 个 DWYG 在肝再生中的潜在靶点，提示 DWYG 可能通过 MAPK、TNF 和 IL-17 等途径发挥作用。此外，还发现槲皮素是 DWYG 的主要成分之一，与三个关键靶点的结合能较低。结论：DWYG 可促进肝再生，槲皮素可能是其核心成分。
