Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey.
Department of Biochemistry, Ataturk University Medical Faculty, Erzurum, Turkey.
Curr Med Res Opin. 2023 Sep;39(9):1263-1270. doi: 10.1080/03007995.2023.2247317. Epub 2023 Aug 21.
Lack of energy, fatigue, debility are often seen in depression and hardly respond to treatment. Finding some biomarkers for these symptoms may be important for diagnosis and treatment. We aimed to investigate the possible relationship between depression and energy-related molecules irisin, adropin and preptin.
There were 117 patients with depression and 59 healthy volunteers included in the study. Sociodemographic characteristics and clinical features of groups were evaluated, and depressed patients were divided into subtypes, then irisin, adropin, preptin levels were compared between depressive patients and healthy controls and between subtypes. Depression severity, quality of life, functionality and the relations with irisin, adropin and preptin levels and associations between depression subtypes were evaluated.
Irisin, adropin, and preptin levels were lower in depression, positively correlated with quality of life, and negatively correlated with depression severity and functional impairment. Depression subtypes showed no difference in irisin, adropin and preptin levels.
We found decreased serum irisin, adropin and preptin levels in depression. Our results may support investigation of irisin, adropin and preptin as biomarkers for depression but it might be more meaningful to evaluate these biomarkers in a long-term follow-up.
乏力、疲劳、虚弱等是抑郁症的常见症状，且对治疗反应不佳。寻找这些症状的生物标志物对于诊断和治疗可能很重要。我们旨在探讨抑郁症与能量相关分子鸢尾素、阿立新和前ptin 之间的可能关系。
本研究纳入了 117 例抑郁症患者和 59 名健康志愿者。评估了两组的社会人口学特征和临床特征，并将抑郁症患者分为亚型，然后比较抑郁患者和健康对照组以及不同亚型之间的鸢尾素、阿立新和前ptin 水平。评估了抑郁症严重程度、生活质量、功能以及与鸢尾素、阿立新和前ptin 水平的关系，以及抑郁症亚型之间的相关性。
抑郁症患者的鸢尾素、阿立新和前ptin 水平较低，与生活质量呈正相关，与抑郁严重程度和功能障碍呈负相关。抑郁症亚型在鸢尾素、阿立新和前ptin 水平上无差异。
我们发现抑郁症患者血清鸢尾素、阿立新和前ptin 水平降低。我们的结果可能支持将鸢尾素、阿立新和前ptin 作为抑郁症的生物标志物进行研究，但在长期随访中评估这些生物标志物可能更有意义。
