Hasanpour-Segherlou Zahra, Butler Andrew A, Candelario-Jalil Eduardo, Hoh Brian L
Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Department of Pharmacology and Physiological Sciences, Saint Louis University, Saint Louis, MO 63104, USA.
Biomolecules. 2024 Dec 17;14(12):1613. doi: 10.3390/biom14121613.
Adropin, a secreted peptide hormone identified in 2008, plays a significant role in regulating energy homeostasis, glucose metabolism, and lipid metabolism. Its expression is linked to dietary macronutrient intake and is influenced by metabolic syndrome, obesity, diabetes, and cardiovascular diseases. Emerging evidence suggests that adropin might be a biomarker for various conditions, including metabolic syndrome, coronary artery disease, and hypertensive disorders complicating pregnancy. In cerebrovascular diseases, adropin demonstrates protective effects by reducing blood-brain barrier permeability, brain edema, and infarct size while improving cognitive and sensorimotor functions in ischemic stroke models. The protective effects of adropin extend to preventing endothelial damage, promoting angiogenesis, and mitigating inflammation, making it a promising therapeutic target for cardiovascular and neurodegenerative diseases. This review provides a comprehensive overview of adropin's multifaceted roles in physiological and pathological conditions, as well as our recent work demonstrating adropin's role in subarachnoid hemorrhage-mediated neural injury and delayed cerebral infarction.
促泌素是2008年发现的一种分泌型肽类激素，在调节能量稳态、葡萄糖代谢和脂质代谢方面发挥着重要作用。其表达与膳食常量营养素摄入有关，并受代谢综合征、肥胖、糖尿病和心血管疾病的影响。新出现的证据表明，促泌素可能是包括代谢综合征、冠状动脉疾病和妊娠合并高血压疾病在内的各种病症的生物标志物。在脑血管疾病中，促泌素通过降低血脑屏障通透性、减轻脑水肿和梗死面积，同时改善缺血性中风模型中的认知和感觉运动功能，发挥保护作用。促泌素的保护作用还包括预防内皮损伤、促进血管生成和减轻炎症，使其成为心血管疾病和神经退行性疾病有前景的治疗靶点。本文综述了促泌素在生理和病理条件下的多方面作用，以及我们最近关于促泌素在蛛网膜下腔出血介导的神经损伤和迟发性脑梗死中作用的研究工作。
