体力活动不足导致痴呆的人群归因分数的系统评价和荟萃分析。
Systematic review and meta-analysis on population attributable fraction for physical inactivity to dementia.
机构信息
Post Graduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Post Graduate Program in Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
出版信息
Alzheimers Dement. 2023 Oct;19(10):4688-4704. doi: 10.1002/alz.13417. Epub 2023 Aug 14.
INTRODUCTION
The number of cases of dementia attributable to physical inactivity remains unclear due to heterogeneity in physical inactivity definitions and statistical approaches used.
METHODS
Studies that used population-based samples to estimate the population attributable fraction (PAF) of physical inactivity for dementia were included in this review. Weighted PAFs were adjusted for communality among the risk factors (i.e., inactive persons may also share other risk factors) analyzed. Values were reported as percentage (%) of cases of dementia attributable to physical inactivity.
RESULTS
We included 22 studies. The overall impact of physical inactivity, defined by any criteria, on dementia ranged from 6.6% (95% CI: 3.6%, 9.6%; weighted) to 16.6% (95% CI: 14.4%, 18.9%; unweighted). Studies using the WHO criterion for physical inactivity estimated a higher unweighted impact (β = 7.3%; 95% CI: 2.0%, 12.6%) than studies using other criteria.
DISCUSSION
Conservatively, one in 15 cases of dementia may be attributable to physical inactivity, defined by any criteria.
简介
由于身体活动定义和使用的统计方法存在异质性，因此归因于身体活动不足的痴呆病例数量仍不清楚。
方法
本综述纳入了使用基于人群样本估计身体活动不足导致痴呆的人群归因分数（PAF）的研究。对分析的风险因素（即，不活跃的人也可能具有其他风险因素）之间的共同性进行了加权 PAF 调整。报告的值表示身体活动不足导致痴呆的病例百分比（%）。
结果
我们纳入了 22 项研究。任何标准定义的身体活动不足对痴呆的总体影响范围为 6.6%（95%CI：3.6%，9.6%；加权）至 16.6%（95%CI：14.4%，18.9%；未加权）。使用世界卫生组织（WHO）身体活动不足标准估计的未加权影响更高（β=7.3%；95%CI：2.0%，12.6%），而使用其他标准的研究则较低。
讨论
保守估计，每 15 例痴呆症中就有 1 例可能归因于身体活动不足，无论使用何种标准来定义。
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