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寡转移前列腺癌——过去十年概述

Oligometastatic carcinoma prostate - An overview of the last decade.

作者信息

Shah Milap J, Sharma Aditya Prakash, Hameed B M Zeeshan, Jain Ravi, Patil Abhijit, Karthickeyan Naganathan, Singh Abhishek

机构信息

Aarogyam Specialty Hospital, Ahmedabad, India.

Department of Urology, PGIMER, Chandigarh, India.

出版信息

Indian J Urol. 2023 Jul-Sep;39(3):195-201. doi: 10.4103/iju.iju_60_23. Epub 2023 Jun 30.

DOI:10.4103/iju.iju_60_23
PMID:37575157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419768/
Abstract

INTRODUCTION

Oligometastatic prostate cancer (OMPC) has gained profound interest lately due to its different tumor biology and our ability to use multimodality therapy for cure or prolonged survival. Selecting the appropriate patient for treatment has become the aim of treating urologists, medical oncologists, and radiation oncologists. Through this review, we try to highlight the management of OMPC in light of recent literature.

METHODS

Literature search was performed on Pubmed, Scopus and Embase using keywords "Oligometastatic", " Prostate Cancer" using operators such as "And" & "Or". Relevant articles were screened and all the latest articles on this emerging entity were included in this review.

RESULTS

All trials relevant to oligometastatic prostate cancer defining the role of surgery, radiotherapy and systemic therapy were included and appropriate inferences were drawn. Relevant studies were compiled in tabular form for this article.

CONCLUSION

The current standard of care of management for OMPC remains systemic therapy on the lines of hormone-sensitive metastatic prostate cancer. The evolving role of surgery, and radiotherapy along with systemic therapy is highlighted in this article.

摘要

引言

寡转移前列腺癌(OMPC)近来引起了广泛关注,因其具有不同的肿瘤生物学特性,且我们有能力采用多模态疗法实现治愈或延长生存期。选择合适的患者进行治疗已成为泌尿外科医生、医学肿瘤学家和放射肿瘤学家的治疗目标。通过本综述,我们试图根据近期文献强调寡转移前列腺癌的治疗。

方法

在PubMed、Scopus和Embase上进行文献检索,使用关键词“寡转移”、“前列腺癌”,并使用“与”和“或”等运算符。筛选相关文章,本综述纳入了关于这个新兴实体的所有最新文章。

结果

纳入了所有与寡转移前列腺癌相关的试验,这些试验明确了手术、放疗和全身治疗的作用,并得出了适当的推论。相关研究以表格形式汇总在本文中。

结论

寡转移前列腺癌目前的标准治疗方案仍是遵循激素敏感性转移性前列腺癌的全身治疗。本文强调了手术、放疗以及全身治疗不断演变的作用。

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What's inside?里面有什么?
Indian J Urol. 2023 Jul-Sep;39(3):181-182. doi: 10.4103/iju.iju_225_23. Epub 2023 Jun 30.

本文引用的文献

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Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials.寡转移前列腺癌转移灶定向治疗与观察的长期结局和反应的遗传预测:STOMP 和 ORIOLE 试验分析。
J Clin Oncol. 2022 Oct 10;40(29):3377-3382. doi: 10.1200/JCO.22.00644. Epub 2022 Aug 24.
2
Where Do We Stand in the Management of Oligometastatic Prostate Cancer? A Comprehensive Review.在寡转移前列腺癌的管理方面我们处于什么位置?一项全面综述。
Cancers (Basel). 2022 Apr 16;14(8):2017. doi: 10.3390/cancers14082017.
3
Safety and efficacy of apalutamide in Japanese patients with metastatic castration-sensitive prostate cancer receiving androgen deprivation therapy: Final report for the Japanese subpopulation analysis of the randomized, placebo-controlled, phase III TITAN study.阿帕鲁胺在接受雄激素剥夺疗法的转移性去势敏感前列腺癌日本患者中的安全性和疗效:TITAN 研究的随机、安慰剂对照、III 期日本亚人群分析的最终报告。
Int J Urol. 2022 Jun;29(6):533-540. doi: 10.1111/iju.14843. Epub 2022 Mar 15.
4
Feasibility and safety of radical prostatectomy for oligo-metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo-Metastases to the bone (TRoMbone) trial.根治性前列腺切除术治疗寡转移前列腺癌的可行性和安全性:前列腺癌和寡转移至骨骼的男性接受根治性前列腺切除术(TRoMbone 试验)。
BJU Int. 2022 Jul;130(1):43-53. doi: 10.1111/bju.15669. Epub 2022 Jan 27.
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