Makinouchi Ryuichiro, Koyama Teppei, Machida Shinji, Imai Naohiko
Department of Internal Medicine Division of Nephrology and Hypertension, St. Marianna University Yokohama Seibu Hospital Yokohama Japan.
Health Sci Rep. 2023 Aug 9;6(8):e1467. doi: 10.1002/hsr2.1467. eCollection 2023 Aug.
Few studies have reported the prevalence and characteristics of hypouricemia in the emergency department (ED). We investigated the prevalence and characteristics of hypouricemia in the ED of a university-affiliated hospital in Japan.
This is a retrospective cross-sectional single-center study. All adult patients (18 years old or older) who had their serum uric acid (SUA) measured at the ED between 2011 and 2021 were included. Information collected included age, sex, SUA, and serum creatinine. Hypouricemia was defined as an SUA level ≦2.0 mg/dL.
A total of 10,551 patients were included in the study. Fifty-one percent were male. The median SUA levels were significantly higher in men than in women (6.0 [4.8-7.4] vs. 4.7 [3.7-6.1], < 0.001). The prevalence of hypouricemia was higher in women than in men (2.0% vs. 0.9%, < 0.001). A possible cause of hypouricemia was identified in 88 patients. Malignancy and diabetes were the major possible cause of hypouricemia ( < 0.001).
The distribution of SUA levels and prevalence of hypouricemia differed significantly by sex and age in the ED. Malignancy was the leading cause of hypouricemia in the ED.
很少有研究报道急诊科低尿酸血症的患病率及特征。我们调查了日本一家大学附属医院急诊科低尿酸血症的患病率及特征。
这是一项回顾性横断面单中心研究。纳入了2011年至2021年间在急诊科测量血清尿酸（SUA）的所有成年患者（18岁及以上）。收集的信息包括年龄、性别、SUA和血清肌酐。低尿酸血症定义为SUA水平≤2.0mg/dL。
共有10551名患者纳入研究。51%为男性。男性的SUA中位数水平显著高于女性（6.0[4.8 - 7.4]对4.7[3.7 - 6.1]，<0.001）。女性低尿酸血症的患病率高于男性（2.0%对0.9%，<0.001）。在88名患者中确定了低尿酸血症的可能原因。恶性肿瘤和糖尿病是低尿酸血症的主要可能原因（<0.001）。
急诊科中SUA水平分布及低尿酸血症患病率在性别和年龄上存在显著差异。恶性肿瘤是急诊科低尿酸血症的主要原因。
