Joo Ji-Young, Park Hae Ryoun, Cho Youngseuk, Noh Yunhwan, Lee Chang Hun, Lee Seung-Geun
Department of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Korea.
Periodontal Disease Signaling Network Research Center, Dental and Life Science Institute, Pusan National University School of Dentistry, Yangsan, Korea.
J Periodontal Implant Sci. 2023 Aug;53(4):283-294. doi: 10.5051/jpis.2202220111. Epub 2023 Jan 6.
The aim of this study was to investigate the relationship between serum uric acid (SUA) levels and the risk of periodontitis in Korean adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES).
This cross-sectional study used data from the KNHANES 2016-2018 and analysed 12,735 Korean adults aged ≥19 years who underwent oral examinations. Hypouricemia was defined as SUA <3 mg/dL in men and <2 mg/dL in women, and hyperuricemia was defined as SUA ≥7 mg/dL in men and ≥6 mg/dL in women.
The weighted prevalence of hypouricemia and hyperuricemia was 0.6% and 12.9%, respectively. The overall weighted periodontitis rate was 30.5%. The frequency of periodontitis in subjects with hypouricemia, normouricemia, and hyperuricemia were 51.1%, 30.3%, and 30.6%, respectively. Study participants with hypouricemia were significantly older, had significantly fasting blood glucose levels, and had better kidney function than non-hypouricemic participants. In univariate logistic regression analyses, hypouricemia was associated with periodontitis, but hyperuricemia was not. The fully adjusted model revealed that the adjusted odds ratio of hypouricemia for periodontitis was 1.62 (95% confidence interval, 1.13-2.33), while the relationship between hyperuricemia and periodontitis in the multivariable logistic regression model was not significant.
The results of this study suggest that hypouricemia is associated with an increased risk of periodontitis.
本研究旨在利用韩国国家健康与营养检查调查（KNHANES）的数据，调查韩国成年人血清尿酸（SUA）水平与牙周炎风险之间的关系。
这项横断面研究使用了KNHANES 2016 - 2018年的数据，分析了12735名年龄≥19岁接受口腔检查的韩国成年人。低尿酸血症定义为男性SUA<3mg/dL，女性SUA<2mg/dL，高尿酸血症定义为男性SUA≥7mg/dL，女性SUA≥6mg/dL。
低尿酸血症和高尿酸血症的加权患病率分别为0.6%和12.9%。总体加权牙周炎患病率为30.5%。低尿酸血症、正常尿酸血症和高尿酸血症患者的牙周炎发生率分别为51.1%、30.3%和30.6%。低尿酸血症的研究参与者比非低尿酸血症参与者年龄显著更大，空腹血糖水平显著更高，肾功能更好。在单因素逻辑回归分析中，低尿酸血症与牙周炎相关，但高尿酸血症与牙周炎无关。完全调整模型显示，低尿酸血症与牙周炎的调整优势比为1.62（95%置信区间，1.13 - 2.33），而在多变量逻辑回归模型中，高尿酸血症与牙周炎之间的关系不显著。
本研究结果表明，低尿酸血症与牙周炎风险增加有关。
