Ali Haider, Rashid-Ul-Amin Syed, Hai Abdul
Department of Nuclear Medicine and molecular imaging, Sindh Institute of Urology and Transplantation (S.I.U.T.), Karachi, Pakistan.
J Cancer Allied Spec. 2023 Aug 13;9(2):529. doi: 10.37029/jcas.v9i2.519. eCollection 2023.
A positron emission tomography (PET) scan and a computed tomography (CT) scan are an integral part of oncological imaging and other modalities such as magnetic resonance imaging, CT or bone scintigraphy have some limitations in staging the workup of prostate carcinoma. Combined with tissue-specific markers like prostate-specific membrane antigen (PSMA), positron emitter-based functional imaging results have improved. Our study aimed to determine the Standardised Uptake Value (SUVmax) in prostate adenocarcinoma that is confined to the organ in Ga-68-PSMA PET-CT scans and how it correlates with prostate-specific antigen (PSA) levels and Gleason score (GS).
This cross-sectional study was conducted at Sindh Institute of Urology and Transplantation (SIUT), Karachi, and includes subjects referred for a Ga68-PSMA PET-CT scan from September 2017 to January 2022. Histopathologic-proven adenocarcinoma prostate patients with organ-confined disease and PSA levels obtained within 6 weeks before the PSMA-PET-CT scan were included in the study. PET-CT images were semi-quantitatively analysed by measuring SUVmax and the result was interpreted using statistical software SPSS version 22.0.
A total of 154 patients were analysed. The mean age of patients was 66.57 ± 8.86 years. The GS of all patients ranges from 6 to 10. The mean and median PSA levels were 32.33 ng/mL (range: 0.004-306.00) and 14.20 ng/mL, respectively. The mean SUVmax of all prostatic lesions was 14.67 ± 12.58 and the median value was 10.76. SUVmax was higher in patients with a PSA level of more than ten than those with a <10. The correlation of SUVmax with PSA and GS showed a significant correlation.
The SUVmax of organ-confined prostate cancer correlates well with PSA level and GS Median SUVmax and PSA directly relate to GS.
正电子发射断层扫描（PET）和计算机断层扫描（CT）是肿瘤成像的重要组成部分，而其他成像方式，如磁共振成像、CT或骨闪烁显像在前列腺癌分期检查中存在一些局限性。结合前列腺特异性膜抗原（PSMA）等组织特异性标志物后，基于正电子发射体的功能成像结果有所改善。我们的研究旨在确定局限于器官内的前列腺腺癌在Ga-68-PSMA PET-CT扫描中的标准化摄取值（SUVmax），以及它与前列腺特异性抗原（PSA）水平和 Gleason评分（GS）的相关性。
本横断面研究在卡拉奇的信德泌尿学与移植研究所（SIUT）进行，纳入了2017年9月至2022年1月期间因Ga68-PSMA PET-CT扫描而转诊的患者。组织病理学证实为前列腺腺癌且疾病局限于器官内，并且在PSMA-PET-CT扫描前6周内获得PSA水平的患者被纳入研究。通过测量SUVmax对PET-CT图像进行半定量分析，并使用统计软件SPSS 22.0对结果进行解读。
共分析了154例患者。患者的平均年龄为66.57±8.86岁。所有患者的GS范围为6至10。PSA的平均水平和中位数分别为32.33 ng/mL（范围：0.004 - 306.00）和14.20 ng/mL。所有前列腺病变的平均SUVmax为14.67±12.58，中位数为10.76。PSA水平大于10的患者的SUVmax高于PSA水平小于10的患者。SUVmax与PSA和GS的相关性显示出显著相关性。
局限于器官内的前列腺癌的SUVmax与PSA水平和GS密切相关。SUVmax中位数和PSA与GS直接相关。
