Li Xue-Xia, Zhang Jun-Tao, Ding Xiao-Ying
State Key Laboratory of Quality Research in Chinese Medicine, Macao University of Science and Technology, Macao, and.
Department of Nephropathy, Zhuhai Hospital of Integrated Chinese and Western Medicine, Zhuhai, Guangdong, China.
Clin Nephrol Case Stud. 2023 Aug 7;11:126-131. doi: 10.5414/CNCS111159. eCollection 2023.
Sinomenine (SIN), the alkaloid monomer extracted from , is a kind of non-steroidal anti-inflammatory drug widely used in China to treat rheumatoid arthritis (RA) and various glomerular diseases. It has various pharmacological effects such as anti-inflammatory, analgesic, and anti-tumor. As a strong histamine-releasing agent, SIN has drawn increasing attention in regards to its side effects such as allergic, gastrointestinal, and circulatory systemic reactions. In this report, we first described a patient with primary membranous nephropathy (PMN) who was treated with oral intake of SIN and developed medicine-induced toxic epidermal necrolysis (TEN) and subsequently died of septic multi-organ failure. The present case report intends to demonstrate the underestimated side effects of SIN that can eventually lead to death.
青藤碱（SIN）是从[植物名称未给出]中提取的生物碱单体，是一种在中国广泛用于治疗类风湿性关节炎（RA）和各种肾小球疾病的非甾体抗炎药。它具有多种药理作用，如抗炎、镇痛和抗肿瘤作用。作为一种强效组胺释放剂，青藤碱因其过敏、胃肠道和循环系统反应等副作用而受到越来越多的关注。在本报告中，我们首次描述了一名原发性膜性肾病（PMN）患者，该患者口服青藤碱后发生药物性中毒性表皮坏死松解症（TEN），随后死于感染性多器官功能衰竭。本病例报告旨在证明青藤碱被低估的副作用，这些副作用最终可能导致死亡。
