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从食物成瘾到酒精成瘾：雄性Wistar大鼠成瘾行为之间的顺序性相互作用

Binging from Food to Alcohol: A Sequential Interaction Between Binging Behaviors in Male Wistar Rats.

作者信息

Cuesta-Martínez Sergio, Ruiz-Leyva Leandro, Jiménez-García Ana María, Aparicio-Mescua Teresa, López-Guarnido Olga, Pautassi Ricardo Marcos, Morón Ignacio, Cendán Cruz Miguel

机构信息

Department of Pharmacology, Biomedical Research Center (CIBM) and Institute of Neuroscience, Faculty of Medicine, University of Granada, Parque Tecnológico de Ciencias de la Salud, 18016, Granada, Spain.

Biosanitary Research Institute, University Hospital Complex of Granada, 18012, Granada, Spain.

出版信息

Bio Protoc. 2023 Aug 5;13(15):e4781. doi: 10.21769/BioProtoc.4781.

DOI:10.21769/BioProtoc.4781
PMID:37575384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10415202/
Abstract

The development of excessive alcohol (ethanol) and/or highly palatable food self-administration is an essential task to elucidate the neurobiological mechanisms that underlie these behaviors. Previous work has highlighted that ethanol self-administration is modulated by both the induction of aversive states (i.e., stress or frustration) and by the concurrent availability of appetitive stimuli (e.g., food). In our protocol, rats are food deprived for three days until they reach 82%-85% of their ad libitum weight. After that, rats are exposed daily for 10 days to a brief binge or control eating experience with highly sugary and palatable food (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively), which is followed by a two-bottle-choice test (ethanol vs. water) in their home cages for 90 min. This model induces robust binge eating, which is followed by a selective increase in ethanol self-administration. Therefore, this protocol allows to study: a) behavioral and neurobiological factors related to binge eating, b) different stages of alcohol use, and c) interactions between the latter and other addictive-like behaviors, like binge eating.

摘要

过度饮酒（乙醇）和/或高度可口食物的自我给药行为的发展，是阐明这些行为背后神经生物学机制的一项重要任务。先前的研究强调，乙醇自我给药行为既受到厌恶状态（如压力或挫败感）的诱导，也受到同时存在的诱人刺激（如食物）的调节。在我们的实验方案中，大鼠禁食三天，直到体重降至其自由进食体重的82%-85%。之后，大鼠每天接受10天的短暂暴饮暴食或对照进食体验，即分别摄入高热量、高可口性食物（即分别为每3分钟摄入11.66千卡和0.97千卡），随后在其饲养笼中进行90分钟的双瓶选择试验（乙醇与水）。该模型可诱导强烈的暴饮暴食行为，随后乙醇自我给药行为会选择性增加。因此，该实验方案可用于研究：a）与暴饮暴食相关的行为和神经生物学因素；b）酒精使用的不同阶段；c）酒精使用与其他成瘾性类似行为（如暴饮暴食）之间的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/6d8177b4cb52/BioProtoc-13-15-4781-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/6ffd42796d35/BioProtoc-13-15-4781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/1718b702ec53/BioProtoc-13-15-4781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/ecae77deaaaa/BioProtoc-13-15-4781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/555a19171b31/BioProtoc-13-15-4781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/6d8177b4cb52/BioProtoc-13-15-4781-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/6ffd42796d35/BioProtoc-13-15-4781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/1718b702ec53/BioProtoc-13-15-4781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/ecae77deaaaa/BioProtoc-13-15-4781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/555a19171b31/BioProtoc-13-15-4781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047a/10415202/6d8177b4cb52/BioProtoc-13-15-4781-g005.jpg

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本文引用的文献

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Addict Biol. 2022 Mar;27(2):e13153. doi: 10.1111/adb.13153.
2
Consummatory Successive Negative Contrast in Rats.大鼠的完成性相继负对比
Bio Protoc. 2019 Apr 5;9(7):e3201. doi: 10.21769/BioProtoc.3201.
3
Sigma-1 antagonism inhibits binge ethanol drinking at adolescence.σ-1受体拮抗剂可抑制青春期的暴饮酒精行为。
Drug Alcohol Depend. 2020 Oct 1;215:108214. doi: 10.1016/j.drugalcdep.2020.108214. Epub 2020 Aug 6.
4
Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking.青春期类似暴饮暴食、对纳洛酮敏感的自愿乙醇摄入量高于成年期，但不会加剧随后的双瓶选择饮酒行为。
Front Behav Neurosci. 2020 Apr 9;14:50. doi: 10.3389/fnbeh.2020.00050. eCollection 2020.
5
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.饮食失调和物质使用相关表型之间的共享遗传风险：来自全基因组关联研究的证据。
Addict Biol. 2021 Jan;26(1):e12880. doi: 10.1111/adb.12880. Epub 2020 Feb 16.
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Frustration Tolerance and Personality Traits in Patients With Substance Use Disorders.物质使用障碍患者的挫折耐受力与人格特质
Front Psychiatry. 2019 Jun 14;10:421. doi: 10.3389/fpsyt.2019.00421. eCollection 2019.
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Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation.环境应激源与酗酒发展：关注分子靶点及其表观遗传调控。
Neurosci Biobehav Rev. 2019 Nov;106:165-181. doi: 10.1016/j.neubiorev.2018.07.004. Epub 2018 Jul 11.
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