Department of Surgery, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, P. O. Box 4236, Accra.
Department of Surgery, Korle Bu Teaching Hospital, P. O. Box 77, Accra.
Ghana Med J. 2022 Dec;56(4):331-335. doi: 10.4314/gmj.v56i4.12.
Anorectal mucosal melanoma (AMM) is a rare, aggressive malignancy. The symptoms of AMM mimic common benign conditions in the anus, such as haemorrhoids; hence diagnosis is often made late, a third of patients having metastasis at first presentation. Surgical resection remains the standard of treatment, and adjuvant therapy is varied, including immunotherapy, brachytherapy, and chemotherapy. The prognosis is poor, with a 5-year survival of 20%. A 65year old woman presented with a five-year history of symptoms suggestive of haemorrhoids and was diagnosed with a malignant anorectal mucosal melanoma after symptoms worsened and further investigation performed. She underwent surgical resection and is currently receiving adjuvant therapy. The prognosis of AMM, the lack of consensus on the treatment regimen to dat and the need for a high index of suspicion for early diagnosis .
None declared.
直肠黏膜黑色素瘤（AMM）是一种罕见的侵袭性恶性肿瘤。AMM 的症状与肛门的常见良性疾病相似，例如痔疮；因此，诊断通常较晚，三分之一的患者在首次就诊时就已经发生转移。手术切除仍然是标准的治疗方法，辅助治疗包括免疫治疗、近距离放射治疗和化疗。预后较差，5 年生存率为 20%。一位 65 岁女性因五年痔疮样症状就诊，症状加重并进一步检查后诊断为直肠黏膜恶性黑色素瘤。她接受了手术切除，目前正在接受辅助治疗。AMM 的预后、目前缺乏治疗方案的共识以及对早期诊断的高度怀疑。
无。
