Salari Arsalan, Ashouri Asieh, Javadzadeh Moghtader Arezoo, Ahmadnia Zahra, Alizadeh Iman
Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Iran J Psychiatry. 2020 Oct;15(4):370-376. doi: 10.18502/ijps.v15i4.4305.
Cardiovascular diseases are the main cause of mortality worldwide. Depression is one of the effective factors in the incidence of cardiovascular diseases like coronary artery stenosis. This study aimed to investigate the relationship between depression symptoms and severity of coronary artery disease (CAD) in patients scheduled for angiography. This prospective, cross sectional research was conducted on as many as 401 patients scheduled to undergo angiography at Dr. Heshmat heart hospital as the referral center in the north of Iran in 2016. Before cardiac catheterization, patients' demographic information (age, gender, level of education, and place of residence) and patients' medical history (history of diabetes mellitus, hypertension, and family history of cardiac disease) were obtained. Also, Beck Depression Questionnaire 2 (BDI II) was completed by a psychologist before angiography. After collecting the data, SPSS v.21 and statistical tests such as Spearman correlation, and Mann-Whitney U regression were used to analyze the data. After controlling for age, sex, and having history of diabetes mellitus, no relation was found between having depression symptoms and more frequency of vessel involvement (OR = 1.35, 95% CI: 0.92 to 1.98, P =0.130) or higher severity of CAD (OR = 1.47, 95% CI: 0.95 to 2.28, P = 0.087). The results were similar for the relation between severity of depression symptoms and CAD extent or CAD severity. The results of this study showed that in patients undergoing angiography, depression symptoms were not related to CAD severity and number of involved vessels. Depression was associated with angina, independently of CAD severity. Our study found no significant correlation between CAD severity and severity of depression. The reason may be that measuring depression at a single time point cannot accurately reveal the impact of this problem on the trend of atherosclerosis over time.
心血管疾病是全球主要的死亡原因。抑郁症是冠状动脉狭窄等心血管疾病发病的有效因素之一。本研究旨在调查计划进行血管造影的患者中抑郁症状与冠状动脉疾病（CAD）严重程度之间的关系。 这项前瞻性横断面研究于2016年在伊朗北部转诊中心赫什马特心脏医院对多达401名计划进行血管造影的患者进行。在心脏导管插入术前，获取患者的人口统计学信息（年龄、性别、教育程度和居住地）以及患者的病史（糖尿病史、高血压史和心脏病家族史）。此外，在血管造影术前由一名心理学家完成贝克抑郁问卷2（BDI II）。收集数据后，使用SPSS v.21以及Spearman相关性分析和Mann-Whitney U回归等统计检验对数据进行分析。 在控制年龄、性别和糖尿病病史后，未发现抑郁症状与血管受累频率增加（OR = 1.35，95% CI：0.92至1.98，P = 0.130）或CAD严重程度更高（OR = 1.47，95% CI：0.95至2.28，P = 0.087）之间存在关联。抑郁症状严重程度与CAD范围或CAD严重程度之间的关系结果相似。 本研究结果表明，在进行血管造影的患者中，抑郁症状与CAD严重程度和受累血管数量无关。抑郁症与心绞痛相关，与CAD严重程度无关。我们的研究发现CAD严重程度与抑郁严重程度之间无显著相关性。原因可能是在单个时间点测量抑郁不能准确揭示该问题对动脉粥样硬化随时间变化趋势的影响。
