Vallejo Paula, Cueva Emily, Martínez-Lozada Pablo, García-Ríos Cecilia A, Miranda-Barros Diego H, Leon-Rojas Jose E
Medical School, Universidad de Las Américas, Quito, ECU.
Medical Research Department, NeurALL Research Group, Quito, ECU.
Cureus. 2023 Jul 11;15(7):e41714. doi: 10.7759/cureus.41714. eCollection 2023 Jul.
Repetitive transcranial magnetic stimulation (rTMS) is an effective method used for the treatment of various neurological diseases, including stroke, epilepsy, and movement disorders. The pathophysiological mechanism for the effect of TMS is not clear. In this literature review, we conducted a detailed search regarding the effect of rTMS on neurotransmission and neuronal plasticity through the modulation of neuronal excitability. Evidence suggests that intramolecular subatomic mechanisms, including genetic changes related to neuronal prevention and death, play an important role. We also discuss the use of rTMS in the rehabilitation of patients with stroke and its main complications, as well as alternative mechanisms related to recovery, emphasizing the findings of available evidence and touching on possible controversies and limitations of the method.
重复经颅磁刺激（rTMS）是一种用于治疗各种神经系统疾病的有效方法，包括中风、癫痫和运动障碍。经颅磁刺激作用的病理生理机制尚不清楚。在这篇文献综述中，我们通过调节神经元兴奋性，对重复经颅磁刺激在神经传递和神经元可塑性方面的作用进行了详细检索。有证据表明，分子内亚原子机制，包括与神经元预防和死亡相关的基因变化，发挥着重要作用。我们还讨论了重复经颅磁刺激在中风患者康复及其主要并发症中的应用，以及与恢复相关的其他机制，强调现有证据的研究结果，并探讨该方法可能存在的争议和局限性。
