阿帕鲁胺引起的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征：病例报告

Martin Gabriella, Lambert Evan, Wang Gordon K

Medical School, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

Family Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

Cureus. 2023 Jul 11;15(7):e41687. doi: 10.7759/cureus.41687. eCollection 2023 Jul.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction that is triggered several weeks after the start of a new medication. This syndrome presents with a variety of clinical symptoms, specifically a manifestation involving a fever followed by a severe rash. A variety of medications are known to trigger DRESS, with the most common being anticonvulsants and allopurinol. Here, we discuss the case of a medication, apalutamide, that caused DRESS in our patient. Early recognition and abrupt discontinuation of the medication is required for the management of this syndrome and to minimize morbidity and mortality.

药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种严重的药物反应，在开始使用新药物数周后引发。该综合征表现出多种临床症状，特别是先发热后出现严重皮疹的表现。已知多种药物可引发DRESS，最常见的是抗惊厥药和别嘌醇。在此，我们讨论一例阿帕鲁胺药物导致我们患者发生DRESS的病例。对于该综合征的管理以及将发病率和死亡率降至最低，需要早期识别并立即停用该药物。