Gustafson Erik A, Santa Rosario Juan C, Rios-Bedoya Carlos, de Socarraz Mariano
CorePlus Servicios Clínicos y Patológicos LLC, Carolina, PR 00983, United States.
McLaren Health Care Corporation, Graduate Medical Education, Grand Blanc, MI 48439, United States.
Gynecol Oncol Rep. 2023 Jul 6;48:101236. doi: 10.1016/j.gore.2023.101236. eCollection 2023 Aug.
The Human Papillomavirus (HPV) causes cervical cancer, the fourth most common cause of death in women in the United States (US). Several major screening clinical trials have demonstrated that high risk HPV (HR-HPV) DNA primary screen is more sensitive at determining the risk of cervical intraepithelial neoplasia level 3 or higher (CIN ≥ 3) than cytology alone and is similar to co-testing. In this cross-sectional study, we characterized a Hispanic population of 18,052 women ages 21-70 years with HR-HPV DNA testing and cytology to determine the prevalence of HR-HPV in the population and determine the likelihood of high grade squamous intraepithelial lesion (HSIL). We also compared cytology, HR-HPV DNA testing, and co-testing strategies to determine sensitivity, specificity, positive predictive value, and negative predictive value for HSIL in cervical biopsies. Results show that HR-HPV had a slightly higher sensitivity (94.2% vs 92.3%) compared to cytology for all high-grade disease (CIN2/3).
人乳头瘤病毒（HPV）可引发宫颈癌，而宫颈癌是美国女性第四大常见死因。多项主要筛查临床试验表明，高危型HPV（HR-HPV）DNA初筛在确定宫颈上皮内瘤变3级或更高级别（CIN≥3）风险方面比单纯细胞学检查更为敏感，且与联合检测效果相似。在这项横断面研究中，我们对18052名年龄在21至70岁的西班牙裔女性进行了HR-HPV DNA检测和细胞学检查，以确定该人群中HR-HPV的患病率，并确定高级别鳞状上皮内病变（HSIL）的可能性。我们还比较了细胞学检查、HR-HPV DNA检测和联合检测策略，以确定宫颈活检中HSIL的敏感性、特异性、阳性预测值和阴性预测值。结果显示，对于所有高级别疾病（CIN2/3），HR-HPV的敏感性略高于细胞学检查（94.2%对92.3%）。
