Yasmin Tahira, Younis Muhammad Numair, Ameer Khalid, Farooq Ahmed, Shahid Abubaker
Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistan.
Department of Orthopaedics, District Headquarter (DHQ) Hospital, Chakwal, Punjab, Pakistan.
Pol J Radiol. 2023 Jul 17;88:e331-e337. doi: 10.5114/pjr.2023.130196. eCollection 2023.
This research study was conducted to evaluate the impact of (Ga)-tagged prostatic-specific membrane antigen (Ga-PSMA) positron emission tomography and computed tomography (PET-CT), compare its role with conventional radiology in early staging of high-risk prostate cancer, and calculate the PSMA score evaluating its usefulness in Ga-PSMA PET-CT reporting in our patient population.
Ga-PSMA PET-CT of 65 high-risk cases of prostate cancer was performed for staging purpo-ses. Any change in disease stage was noted after Ga-PSMA PET-CT findings and PSMA score leading to a change in the management plan.
Change in disease stage post-PSMA imaging was seen in 39% cases, high PSMA score (03) was noted in > 80% of upstaged cases, while low score (0) and (1) was seen in 65% and 35% down-staged individuals, respectively. Change in therapeutic decision-making was observed in 32% (21) of patients.
Ga-PSMA PET-CT scans have a significant influence on the planned clinical management of high-risk prostate cancer patients; hence, they can be utilized as a replacement for radiological imaging tools, particularly in the detection of pelvic nodal and distant metastatic disease. PSMA score can be considered as an effective tool in standardized reporting of Ga-PSMA imaging.
本研究旨在评估镓（Ga）标记的前列腺特异性膜抗原（Ga-PSMA）正电子发射断层扫描和计算机断层扫描（PET-CT）的影响，比较其与传统放射学在高危前列腺癌早期分期中的作用，并计算PSMA评分以评估其在我们患者群体的Ga-PSMA PET-CT报告中的有用性。
对65例高危前列腺癌病例进行Ga-PSMA PET-CT检查以进行分期。根据Ga-PSMA PET-CT结果和PSMA评分导致管理计划改变后，记录疾病分期中的任何变化。
39%的病例在PSMA成像后疾病分期发生变化，80%以上的分期上调病例PSMA评分高（03），而分期下调的个体中，65%和35%的病例分别出现低分（0）和（1）。32%（21例）患者的治疗决策发生了变化。
Ga-PSMA PET-CT扫描对高危前列腺癌患者的计划临床管理有重大影响；因此，它们可作为放射学成像工具的替代品，特别是在检测盆腔淋巴结和远处转移疾病方面。PSMA评分可被视为Ga-PSMA成像标准化报告中的有效工具。
