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远端搭桥手术后的流变学疗法。

Rheocarna therapy after distal bypass surgery.

作者信息

Nakamura Yasuhito, Kumada Yoshitaka, Kawai Norikazu, Ishida Narihiro

机构信息

Department of Cardiovascular Surgery, Matsunami General Hospital, Gifu, Japan.

出版信息

SAGE Open Med. 2023 Aug 10;11:20503121231192813. doi: 10.1177/20503121231192813. eCollection 2023.

DOI:10.1177/20503121231192813
PMID:37576565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10422887/
Abstract

Rheocarna therapy has recently been reported to improve peripherally measured blood flow as an adjuvant treatment after revascularization in patients with chronic limb-threatening ischemia. We investigated whether skin perfusion pressure and continuous walking distance were improved by performing Rheocarna therapy after distal bypass surgery. This study included 10 patients who underwent Rheocarna therapy after distal bypass surgery between June 2022 and March 2023. Rheocarna therapy was performed five times after distal bypass surgery, and the skin perfusion pressure and continuous walking distance after distal bypass surgery were compared with those after Rheocarna therapy. The average age was 74.7 years, and nine patients (90%) were male. All patients were undergoing dialysis, with an average of 14.5 years of dialysis history. There were six patients (60%) with diabetes mellitus and five (50%) with hyperlipidemia. The ankle-brachial index was 0.62 ± 0.36 before distal bypass surgery and 0.936 ± 0.16 after Rheocarna therapy, indicating a significant increase ( = 0.0117). Skin perfusion pressure dorsalis pedis was 71.5 ± 27.0 mmHg after Rheocarna therapy, showing a marked increase from the preoperative value ( = 0.0020). Skin perfusion pressure planta pedis was 65.0 ± 26.3 mmHg after Rheocarna therapy, which was a significant increase from the preoperative value ( = 0.0293). The continuous walking distance was 78.5 ± 102.7 m after the Rheocarna therapy, which was a significant increase from the preoperative value ( = 0.0039). The skin perfusion pressure and continuous walking distance were significantly improved by Rheocarna therapy after distal bypass surgery.

摘要

最近有报道称,流变卡纳疗法(Rheocarna therapy)作为慢性肢体威胁性缺血患者血管重建术后的辅助治疗,可改善外周测量的血流。我们研究了在远端旁路手术后进行流变卡纳疗法是否能改善皮肤灌注压和持续行走距离。本研究纳入了2022年6月至2023年3月期间在远端旁路手术后接受流变卡纳疗法的10例患者。在远端旁路手术后进行了5次流变卡纳疗法,并将远端旁路手术后的皮肤灌注压和持续行走距离与流变卡纳疗法后的进行了比较。平均年龄为74.7岁,9例(90%)为男性。所有患者均在接受透析,平均透析病史为14.5年。有6例(60%)患有糖尿病,5例(50%)患有高脂血症。远端旁路手术前踝肱指数为0.62±0.36,流变卡纳疗法后为0.936±0.16,差异有统计学意义(=0.0117)。流变卡纳疗法后足背皮肤灌注压为71.5±27.0 mmHg,较术前值显著升高(=0.0020)。流变卡纳疗法后足底皮肤灌注压为65.0±26.3 mmHg,较术前值显著升高(=0.0293)。流变卡纳疗法后持续行走距离为78.5±102.7 m,较术前值显著增加(=0.0039)。远端旁路手术后进行流变卡纳疗法可显著改善皮肤灌注压和持续行走距离。

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本文引用的文献

1
A novel low-density lipoprotein/fibrinogen apheresis method for chronic limb-threatening ischemia in patients with poor options for revascularization: A multicenter, single-arm clinical trial.一种新型的低密度脂蛋白/纤维蛋白原吸附法治疗血管重建选择差的慢性肢体威胁性缺血患者:一项多中心、单臂临床试验。
Ther Apher Dial. 2023 Apr;27(2):361-369. doi: 10.1111/1744-9987.13915. Epub 2022 Aug 16.
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Rheocarna as an alternative therapeutic option for patients with chronic limb-threatening ischemia: A case report.Rheocarna作为慢性肢体威胁性缺血患者的一种替代治疗选择:一例病例报告。
SAGE Open Med Case Rep. 2023 Jan 17;11:2050313X221149359. doi: 10.1177/2050313X221149359. eCollection 2023.
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