Murugappan Sivasubramanian, Tofail Syed A M, Thorat Nanasaheb D
Department of Physics, Bernal Institute and Limerick Digital Cancer Research Centre (LDCRC) University of Limerick, Castletroy, Limerick V94T9PX, Ireland.
ACS Omega. 2023 Jul 27;8(31):27845-27861. doi: 10.1021/acsomega.3c01848. eCollection 2023 Aug 8.
Brain cancer is one of those few cancers with very high mortality and low five-year survival rate. First and foremost reason for the woes is the difficulty in diagnosing and monitoring the progression of brain tumors both benign and malignant, noninvasively and in real time. This raises a need in this hour for a tool to diagnose the tumors in the earliest possible time frame. On the other hand, Raman spectroscopy which is well-known for its ability to precisely represent the molecular markers available in any sample given, including biological ones, with great sensitivity and specificity. This has led to a number of studies where Raman spectroscopy has been used in brain tumors in various ways. This review article highlights the fundamentals of Raman spectroscopy and its types including conventional Raman, SERS, SORS, SRS, CARS, etc. are used in brain tumors for diagnostics, monitoring, and even theragnostics, collating all the major works in the area. Also, the review explores how Raman spectroscopy can be even more effectively used in theragnostics and the clinical level which would make them a one-stop solution for all brain cancer needs in the future.
脑癌是少数死亡率极高且五年生存率很低的癌症之一。造成这种困境的首要原因是难以对良性和恶性脑肿瘤的进展进行非侵入性实时诊断和监测。这使得当下急需一种能够在尽可能早的时间范围内诊断肿瘤的工具。另一方面，拉曼光谱以其能够高度灵敏且特异地表征任何给定样品（包括生物样品）中可用的分子标记而闻名。这引发了许多研究，其中拉曼光谱已被以各种方式用于脑肿瘤研究。这篇综述文章重点介绍了拉曼光谱的基本原理及其类型，包括传统拉曼光谱、表面增强拉曼光谱（SERS）、表面拉曼散射（SORS）、受激拉曼散射（SRS）、相干反斯托克斯拉曼散射（CARS）等，这些光谱在脑肿瘤的诊断、监测甚至治疗诊断中都有应用，本文整理了该领域的所有主要研究成果。此外，该综述探讨了拉曼光谱如何能在治疗诊断及临床层面得到更有效的应用，这将使它们在未来成为满足所有脑癌需求的一站式解决方案。
